Schizophrenia and anteroventral thalamic nucleus: Selective decrease of parvalbumin-immunoreactive thalamocortical projection neurons

Peter Danos, Bruno Baumann, Hans Gert Bernstein, Michael Franz, Renate Stauch, Georg Northoff, Dieter Krell, Peter Falkai, Bernhard Bogerts

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122 引文 斯高帕斯(Scopus)

摘要

This study was designed to examine possible anatomical changes of thalamocortical circuits in schizophrenics. Previous immunocytochemical studies have shown that parvalbumin, a calcium-binding protein, occurs in thalamocortical projection neurons, but not in GABAergic interneurons in the anteroventral thalamic nucleus (AN). Using parvalbumin-immunocytochemistry we investigated the densities of thalamocortical projection neurons in the AN of schizophrenic cases (n = 12) and controls (n = 14). The densities of all neurons in the AN were estimated by Nissl-staining. The majority of thalamocortical projection neurons in AN were identified by parvalbumin- immunoreaction. Significantly reduced densities of thalamocortical projection neurons were estimated in the right (P = 0.003) and left AN (P = 0.018) in schizophrenic subjects. The densities of all neurons in right and left AN were also diminished in schizophrenics; however, these decreases did not reach statistical significance. The reductions of parvalbumin-positive thalamocortical projection neurons were not correlated with the length of disease, this finding supporting the neurodevelopmental etiology of structural abnormalities in schizophrenia.
原文英語
頁(從 - 到)1-10
頁數10
期刊Psychiatry Research - Neuroimaging
82
發行號1
DOIs
出版狀態已發佈 - 四月 10 1998

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 放射學、核子醫學和影像學
  • 生物精神病學
  • 心理學(全部)

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