Safety evaluation of nano/sub-microsized lignan glycosides from sesame meal

Wei Lun Hung, Chi Hua Lu, Chia Ding Liao, Lucy Sun Hwang

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from sesame meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from sesame meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the "no observed adverse effect levels" (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for sesame lignan glycosides.
原文英語
頁(從 - 到)129-136
頁數8
期刊Food Control
30
發行號1
DOIs
出版狀態已發佈 - 三月 1 2013
對外發佈Yes

指紋

sesame meal
Sesamum
Lignans
lignans
Glycosides
Meals
glycosides
drug toxicity
Safety
mutagenicity
ingredients
Ames test
chromosome aberrations
assays
Chromosome Aberrations
wet milling
No-Observed-Adverse-Effect Level
no observed adverse effect level
Micronucleus Tests
nanotechnology

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

引用此文

Safety evaluation of nano/sub-microsized lignan glycosides from sesame meal. / Hung, Wei Lun; Lu, Chi Hua; Liao, Chia Ding; Hwang, Lucy Sun.

於: Food Control, 卷 30, 編號 1, 01.03.2013, p. 129-136.

研究成果: 雜誌貢獻文章

Hung, Wei Lun ; Lu, Chi Hua ; Liao, Chia Ding ; Hwang, Lucy Sun. / Safety evaluation of nano/sub-microsized lignan glycosides from sesame meal. 於: Food Control. 2013 ; 卷 30, 編號 1. 頁 129-136.
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abstract = "Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from sesame meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from sesame meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the {"}no observed adverse effect levels{"} (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for sesame lignan glycosides.",
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AB - Nanotechnology is an emerging field in the food industry, but the potential hazards and toxicities of nano-sized food ingredients are still not clear. The aim of this study was to evaluate the mutagenicity and oral toxicity of nano/submicro-sized ingredient, lignan glycosides from sesame meal (N-LGSM), prepared by a wet-milling method to reduce the average particle size to 189 nm. Genotoxicity assays including Ames test, chromosome aberration assay, micronuclei assay and a 28-day subacute oral toxicity assay were employed to evaluate the mutagenicity and oral toxicity. Results of the Ames test showed that neither lignan glycosides from sesame meal (LGSM) nor N-LGSM increased mutagenicity toward Salmonella typhimurium strains TA97, TA98, TA100, TA102 and TA1535. Furthermore, LGSM and N-LGSM were found to have no mutagenic effects on increasing chromosome aberrations in treated Chinese Hamster Ovary (CHO) cells and the number of micronuclei in mouse erythrocytes. Most importantly, in the 28-day subacute oral toxicity trial, the "no observed adverse effect levels" (NOAELs) of LGSM and N-LGSM were determined to be 1000 and 200 mg/kg/day, respectively for both male and female mice. In conclusion, the nano/submicrosizing process did not cause the mutagenicity and oral toxicity for LGSM, and therefore it is a safe processing method for sesame lignan glycosides.

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