Safety and efficacy of mixing cetrorelix with follitropin alfa: a randomized study

Yu Hung Lin, Yeong-Ray Wen, Yuan-May Chang, Kok Min Seow, Bih Chwen Hsieh, Jiann-Loung Hwang, Chii Ruey Tzeng

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Objective: To assess the safety and efficacy of mixing cetrorelix with follitropin alfa (rFSH) in assisted reproductive technology. Design: Prospective, randomized study. Setting: An IVF center in a teaching hospital. Patient(s): One hundred forty patients undergoing intracytoplasmic sperm injection were randomized into mixed (M) or separate (S) injection groups. Intervention(s): In the M group, rFSH and cetrorelix were mixed immediately before administration, whereas in the S group, rFSH and cetrorelix were administered separately. Main Outcome Measure(s): The primary efficacy end point was the incidence of premature LH surge. The secondary efficacy endpoints included estradiol levels on the day of hCG injection, numbers of oocytes obtained, implantation, and ongoing pregnancy rates. The safety endpoints included ovarian hyperstimulation syndrome, and adverse events related to injections including local tolerability. Result(s): Excluding eight patients who dropped out of the study, there were 66 patients in each group for analysis. Patients in the M group received significantly fewer injections than patients in the S group (9.1 vs. 13.9). Other outcome parameters, including incidences of premature LH surge, numbers of oocytes retrieved, fertilization, implantation, and ongoing pregnancy rates were similar between the two groups. Conclusion(s): Cetrorelix and rFSH can be mixed together without compromising their reported safety and efficacy. This observation is in line with the reported safety and efficacy profile of the products listed in their current package inserts.
原文英語
頁(從 - 到)179-183
頁數5
期刊Fertility and Sterility
94
發行號1
DOIs
出版狀態已發佈 - 六月 2010

ASJC Scopus subject areas

  • 生殖醫學
  • 婦產科

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