Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring

Chun Jieh Hsu, Yu Chia Kan, Chun Wei Lee, Jen Kuei Wu, Kang Yun Lee, Po Hao Feng, Wei Chiao Chang, Fan Gang Tseng

研究成果: 書貢獻/報告類型會議貢獻

摘要

In the present study, we indicated that the detection of specific subtypes of circulating tumor microemboli (CTM) in post-operative patients could help predict cancer recurrence. By using conventional strategies for detection of non-small-cell lung cancer (NSCLC) circulating tumor cells, is significantly limited due to inherently heterogeneous and dynamic expression of EpCAM, and degradation of cytokeratins during epithelial-tomesenchymal transition. These lead to non-negligible false negative detection of “uncapturable and invisible” single CTCs. To solve the problem, we investigated the clinical significance of CTM subtypes, including single CTCs, multi-CTCs cluster, and WBC-CTCs cluster on SACA chip for studying cancer metastasis and recurrence in patients with lung adenocarcinoma.

原文英語
主出版物標題MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
發行者Chemical and Biological Microsystems Society
頁面1141-1142
頁數2
ISBN(電子)9781733419017
出版狀態已發佈 - 2020
事件24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
持續時間: 十月 4 2020十月 9 2020

出版系列

名字MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

會議

會議24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
城市Virtual, Online
期間10/4/2010/9/20

ASJC Scopus subject areas

  • 化學工程(雜項)
  • 生物工程
  • 化學 (全部)
  • 控制與系統工程

指紋

深入研究「Saca chip enabled circulating tumor cell clusters phenotyping for cancer immunotherapy response monitoring」主題。共同形成了獨特的指紋。

引用此