S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors

Hsien Wei Yeh, Tzung Sheng Lin, Hsiao Wen Wang, Hou Wen Cheng, Der Zen Liu, Pi Hui Liang

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.

原文英語
頁(從 - 到)11518-11528
頁數11
期刊Organic and Biomolecular Chemistry
13
發行號47
DOIs
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • 生物化學
  • 物理與理論化學
  • 有機化學

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