摘要
Objective: We aimed to probe for regional cerebral effects of S-ketamine on in vivo GABA-A-receptor binding in healthy human subjects. Methods: We investigated I-123-iomazenil SPECT before, during and after administration of S-ketamine in a blinded placebo-controlled study design (n = 12 in both groups). Analyses of SPECT were performed with voxel-based statistical parametric mapping (SPM), and statistical comparisons were made between the groups. We also assessed biochemical and behavioural changes during S-ketamine infusion. Results: S-ketamine induced positive and negative symptoms measured by the Brief Psychiatric Rating scale (BPRS). It increased the cortisol and prolactin levels. Image analysis revealed significantly decreased I-123-iomazenil binding in bilateral dorsomedial prefrontal cortex during S-ketamine administration when compared to placebo. Conclusion: Our study delivers preliminary evidence for an in vivo interaction of S-ketamine with GABA-A-receptors in human dorsomedial prefrontal cortex.
原文 | 英語 |
---|---|
頁(從 - 到) | 549-554 |
頁數 | 6 |
期刊 | Human Psychopharmacology |
卷 | 23 |
發行號 | 7 |
DOIs | |
出版狀態 | 已發佈 - 2008 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 神經病學(臨床)
- 精神病學和心理健康
- 神經內科
- 藥學(醫學)