摘要

RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularly under oxidative stress, remains largely unknown. In this study, we investigated the role of RRM2B underoxidative stress-induced DNA damage and further examined the regulation of mitochondrial and inflammatory genes by RRM2B. Our study is the first to report the critical role of RRM2B in mitochondrial homeostasis and the inflammation signaling pathway in a p53-independent manner. Furthermore, our study provides novel insights into the role of the RR in inflammatory diseases.
原文英語
文章編號287345
期刊Mediators of Inflammation
2015
DOIs
出版狀態已發佈 - 2015

指紋

Ribonucleotide Reductases
Oxidative Stress
Inflammation
Mitochondrial Genes
DNA Damage
Homeostasis

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

引用此文

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title = "RRM2B-mediated regulation of mitochondrial activity and inflammation under oxidative stress",
abstract = "RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularly under oxidative stress, remains largely unknown. In this study, we investigated the role of RRM2B underoxidative stress-induced DNA damage and further examined the regulation of mitochondrial and inflammatory genes by RRM2B. Our study is the first to report the critical role of RRM2B in mitochondrial homeostasis and the inflammation signaling pathway in a p53-independent manner. Furthermore, our study provides novel insights into the role of the RR in inflammatory diseases.",
author = "Cho, {Er Chieh} and Kuo, {Mei Ling} and Cheng, {Jia Hui} and Cheng, {Yu Chi} and Hsieh, {Yi Chen} and Liu, {Yun Ru} and Hsieh, {Rong Hong} and Yun Yen",
year = "2015",
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AU - Cho, Er Chieh

AU - Kuo, Mei Ling

AU - Cheng, Jia Hui

AU - Cheng, Yu Chi

AU - Hsieh, Yi Chen

AU - Liu, Yun Ru

AU - Hsieh, Rong Hong

AU - Yen, Yun

PY - 2015

Y1 - 2015

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AB - RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularly under oxidative stress, remains largely unknown. In this study, we investigated the role of RRM2B underoxidative stress-induced DNA damage and further examined the regulation of mitochondrial and inflammatory genes by RRM2B. Our study is the first to report the critical role of RRM2B in mitochondrial homeostasis and the inflammation signaling pathway in a p53-independent manner. Furthermore, our study provides novel insights into the role of the RR in inflammatory diseases.

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