Rosmarinus officinalis extract suppresses propionibacterium acnes-induced inflammatory responses

Tsung-Hsien Tsai, Lu Te Chuang, Tsung Jung Lien, Yau Rong Liing, Wei Yu Chen, Po Jung Tsai

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes-induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes-stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes-induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes-induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes-induced inflammation.
原文英語
頁(從 - 到)324-333
頁數10
期刊Journal of Medicinal Food
16
發行號4
DOIs
出版狀態已發佈 - 四月 1 2013

指紋

Rosmarinus
Propionibacterium acnes
Inflammation
NF-kappa B
Interleukin-8
Interleukin-1
Toll-Like Receptor 2
Intradermal Injections
Messenger RNA
Acne Vulgaris
Anti-Infective Agents
Ear
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Cytokines

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

引用此文

Rosmarinus officinalis extract suppresses propionibacterium acnes-induced inflammatory responses. / Tsai, Tsung-Hsien; Chuang, Lu Te; Lien, Tsung Jung; Liing, Yau Rong; Chen, Wei Yu; Tsai, Po Jung.

於: Journal of Medicinal Food, 卷 16, 編號 4, 01.04.2013, p. 324-333.

研究成果: 雜誌貢獻文章

Tsai, Tsung-Hsien ; Chuang, Lu Te ; Lien, Tsung Jung ; Liing, Yau Rong ; Chen, Wei Yu ; Tsai, Po Jung. / Rosmarinus officinalis extract suppresses propionibacterium acnes-induced inflammatory responses. 於: Journal of Medicinal Food. 2013 ; 卷 16, 編號 4. 頁 324-333.
@article{fb9bd5b583ee460ba7a8bbaaccf403b6,
title = "Rosmarinus officinalis extract suppresses propionibacterium acnes-induced inflammatory responses",
abstract = "Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes-induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes-stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes-induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes-induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes-induced inflammation.",
keywords = "anti-inflammation, NF-jB, Propionibacterium acnes, rosemary, TLR2",
author = "Tsung-Hsien Tsai and Chuang, {Lu Te} and Lien, {Tsung Jung} and Liing, {Yau Rong} and Chen, {Wei Yu} and Tsai, {Po Jung}",
year = "2013",
month = "4",
day = "1",
doi = "10.1089/jmf.2012.2577",
language = "English",
volume = "16",
pages = "324--333",
journal = "Journal of Medicinal Food",
issn = "1096-620X",
publisher = "Mary Ann Liebert Inc.",
number = "4",

}

TY - JOUR

T1 - Rosmarinus officinalis extract suppresses propionibacterium acnes-induced inflammatory responses

AU - Tsai, Tsung-Hsien

AU - Chuang, Lu Te

AU - Lien, Tsung Jung

AU - Liing, Yau Rong

AU - Chen, Wei Yu

AU - Tsai, Po Jung

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes-induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes-stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes-induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes-induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes-induced inflammation.

AB - Propionibacterium acnes is a key pathogen involved in the progression of acne inflammation. The development of a new agent possessing antimicrobial and anti-inflammatory activity against P. acnes is therefore of interest. In this study, we investigated the inhibitory effect of rosemary (Rosmarinus officinalis) extract on P. acnes-induced inflammation in vitro and in vivo. The results showed that ethanolic rosemary extract (ERE) significantly suppressed the secretion and mRNA expression of proinflammatory cytokines, including interleukin (IL)-8, IL-1β, and tumor necrosis factor-α in P. acnes-stimulated monocytic THP-1 cells. In an in vivo mouse model, concomitant intradermal injection of ERE attenuated the P. acnes-induced ear swelling and granulomatous inflammation. Since ERE suppressed the P. acnes-induced nuclear factor kappa-B (NF-κB) activation and mRNA expression of Toll-like receptor (TLR) 2, the suppressive effect of ERE might be due, at least partially, to diminished NF-κB activation and TLR2-mediated signaling pathways. Furthermore, three major constituents of ERE, carnosol, carnosic acid, and rosmarinic acid, exerted different immumodulatory activities in vitro. In brief, rosmarinic acid significantly suppressed IL-8 production, while the other two compounds inhibited IL-1β production. Further study is needed to explore the role of bioactive compounds of rosemary in mitigation of P. acnes-induced inflammation.

KW - anti-inflammation

KW - NF-jB

KW - Propionibacterium acnes

KW - rosemary

KW - TLR2

UR - http://www.scopus.com/inward/record.url?scp=84876117206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876117206&partnerID=8YFLogxK

U2 - 10.1089/jmf.2012.2577

DO - 10.1089/jmf.2012.2577

M3 - Article

C2 - 23514231

AN - SCOPUS:84876117206

VL - 16

SP - 324

EP - 333

JO - Journal of Medicinal Food

JF - Journal of Medicinal Food

SN - 1096-620X

IS - 4

ER -