Roles of hepatic progenitor cells activation, ductular reaction proliferation and notch signaling in morbid obesity

Phui Ly Liew, Weu Wang, Yi Chih Lee, Ming Te Huang, Wei Jei Lee

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p

原文英語
頁(從 - 到)1921-1927
頁數7
期刊Hepato-Gastroenterology
59
發行號118
DOIs
出版狀態已發佈 - 九月 2012

指紋

Morbid Obesity
Hepatocytes
Stem Cells
Notch Receptors
Keratin-7
Keratin-19
Liver Function Tests
Liver Diseases
Ligands
Biopsy

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

引用此文

Roles of hepatic progenitor cells activation, ductular reaction proliferation and notch signaling in morbid obesity. / Liew, Phui Ly; Wang, Weu; Lee, Yi Chih; Huang, Ming Te; Lee, Wei Jei.

於: Hepato-Gastroenterology, 卷 59, 編號 118, 09.2012, p. 1921-1927.

研究成果: 雜誌貢獻文章

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abstract = "Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p",
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AU - Lee, Yi Chih

AU - Huang, Ming Te

AU - Lee, Wei Jei

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N2 - Background/Aims: Hepatic progenitor cells (HPCs) activation, proliferative ductular reaction (DR), replicative arrest and Notch signaling have been demonstrated in a variety of human liver diseases. The relationships are poorly understood in morbid obesity. We investigated factors responsible for the HPCs/DR, replicative arrest and Notch signaling in non-NASH and NASH groups. Methodology: Cytokeratin 7 (and 19), p21, CD34, Ki67 and different Notch receptors and ligands immunohistochemical stained biopsies from morbid obese patients with non-NASH (n=10) and NASH (n=25) were studied. These results were correlated with clinicopathological variables. Results: NASH patients presented with abnormal liver function tests and had higher HbA1c percentage. Strong association between HPCs and DR was seen (r=0.785, p

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