摘要

Adiponectin (APN) is an adipokine shown to have potent antiobesity, antiatherosclerotic, suppression of macrophage-to-foam cell transformation, and inhibition of proinflammatory cytokines. Studies have revealed that plasma concentration of APN is approximately three times higher in patients with end-stage kidney disease than in healthy people. However, low plasma levels of the hormone have been shown to elicit a protective effect against inflammation in animal models of ischemia/reperfusion-induced acute renal failure. This review summarizes the possible molecular signaling pathways involved in the effects of APN accumulation in the circulation on acute kidney injury in humans and in rodents.
原文英語
頁(從 - 到)145-148
頁數4
期刊Journal of Experimental and Clinical Medicine(Taiwan)
4
發行號3
DOIs
出版狀態已發佈 - 六月 2012

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Roles of Adiponectin in Acute Kidney Injury」主題。共同形成了獨特的指紋。

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