Role of oxygen-derived free radicals in the mechanism of cysteamine-induced duodenal ulcer in rats

S. H. Chen, S. Pan, K. Okita, T. Takemoto

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

In this study, the possible role of oxygen-derived free radicals in cysteamine-induced duodenal ulcers in rats was investigated. Separate groups of rats were treated with 350 mg/kg cysteamine subcutaneously. Superoxide dismutase (SOD) activity and thiobarbituric acid (TBA) reactants in the duodenal mucosa were analyzed one, three, six, 12 and 24 hours after treatment, respectively. Cu,Zn-SOD activity significantly decreased from 41.79 ± 3.53 NU/mg protein to 29.56 ± 3.62, 27.23 ± 3.02 and 24.64 ± 3.07 NU/mg protein at three, six and 12 hours, respectively. TBA reactants, indicators of tissue injury by oxygen-derived free radicals, significantly increased from 0.18 ± 0.10 nmol/mg protein to 1.31 ± 0.12 and 1.57 ± 0.09 nmol/mg protein at six and 12 hours after cysteamine treatment, respectively. We conclude that an increase of oxygen-derived free radicals and a decrease of Cu,Zn-SOD activity in the duodenal mucosa may be involved in the pathogenesis of cysteamine-induced duodenal ulcers in rats.
原文英語
頁(從 - 到)11-14
頁數4
期刊Journal of the Formosan Medical Association
93
發行號1
出版狀態已發佈 - 1994

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Role of oxygen-derived free radicals in the mechanism of cysteamine-induced duodenal ulcer in rats」主題。共同形成了獨特的指紋。

  • 引用此