Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice

Jing-Huei Lai, Tobias E Karlsson, John Chung-Che Wu, Chi-Zong Huang, Yen-Hua Chen, Shuo-Jhen Kang, Alvin T S Brodin, Barry J Hoffer, Lars Olson, Yung-Hsiao Chiang, Kai-Yun Chen

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Mild traumatic brain injury (mTBI) constitutes 75 ∼ 90% of all TBI cases and causes various physical, cognitive, emotional, and other psychological symptoms. Nogo receptor 1 (NgR1) is a regulator of structural brain plasticity during development and in adulthood. Here, we used mice that, in the absence of doxycycline, overexpress NgR1 in forebrain neurons (MemoFlex) to determine the role of NgR1 in recovery from mTBI with respect to balance, cognition, memory, and emotion. We compared wild-type (WT), MemoFlex, and MemoFlex + doxycycline mice to the same three groups subjected to mTBI. mTBI was induced by a controlled 30-g weight drop. We found that inability to downregulate NgR1 significantly impairs recovery from mTBI-induced impairments. When the NgR1 transgene was turned off, recovery was similar to that of WT mice. The results suggest that the ability to regulate NgR1 signaling is needed for optimal recovery of motor coordination and balance, spatial memory, cognition, and emotional functions after mTBI.
原文英語
期刊Journal of Neurotrauma
DOIs
出版狀態打印前電子出版 - 十一月 17 2018

指紋

Brain Concussion
Cognition
Emotions
Doxycycline
Aptitude
Prosencephalon
Transgenes
Nogo Receptor 1
Down-Regulation
Psychology
Neurons
Weights and Measures
Brain

引用此文

Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice. / Lai, Jing-Huei; Karlsson, Tobias E; Wu, John Chung-Che; Huang, Chi-Zong; Chen, Yen-Hua; Kang, Shuo-Jhen; Brodin, Alvin T S; Hoffer, Barry J; Olson, Lars; Chiang, Yung-Hsiao; Chen, Kai-Yun.

於: Journal of Neurotrauma, 17.11.2018.

研究成果: 雜誌貢獻文章

Lai, Jing-Huei ; Karlsson, Tobias E ; Wu, John Chung-Che ; Huang, Chi-Zong ; Chen, Yen-Hua ; Kang, Shuo-Jhen ; Brodin, Alvin T S ; Hoffer, Barry J ; Olson, Lars ; Chiang, Yung-Hsiao ; Chen, Kai-Yun. / Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice. 於: Journal of Neurotrauma. 2018.
@article{708aa3dfc78a414d9555bd858e0bf6fc,
title = "Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice",
abstract = "Mild traumatic brain injury (mTBI) constitutes 75 ∼ 90{\%} of all TBI cases and causes various physical, cognitive, emotional, and other psychological symptoms. Nogo receptor 1 (NgR1) is a regulator of structural brain plasticity during development and in adulthood. Here, we used mice that, in the absence of doxycycline, overexpress NgR1 in forebrain neurons (MemoFlex) to determine the role of NgR1 in recovery from mTBI with respect to balance, cognition, memory, and emotion. We compared wild-type (WT), MemoFlex, and MemoFlex + doxycycline mice to the same three groups subjected to mTBI. mTBI was induced by a controlled 30-g weight drop. We found that inability to downregulate NgR1 significantly impairs recovery from mTBI-induced impairments. When the NgR1 transgene was turned off, recovery was similar to that of WT mice. The results suggest that the ability to regulate NgR1 signaling is needed for optimal recovery of motor coordination and balance, spatial memory, cognition, and emotional functions after mTBI.",
author = "Jing-Huei Lai and Karlsson, {Tobias E} and Wu, {John Chung-Che} and Chi-Zong Huang and Yen-Hua Chen and Shuo-Jhen Kang and Brodin, {Alvin T S} and Hoffer, {Barry J} and Lars Olson and Yung-Hsiao Chiang and Kai-Yun Chen",
year = "2018",
month = "11",
day = "17",
doi = "10.1089/neu.2018.5949",
language = "English",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",

}

TY - JOUR

T1 - Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice

AU - Lai, Jing-Huei

AU - Karlsson, Tobias E

AU - Wu, John Chung-Che

AU - Huang, Chi-Zong

AU - Chen, Yen-Hua

AU - Kang, Shuo-Jhen

AU - Brodin, Alvin T S

AU - Hoffer, Barry J

AU - Olson, Lars

AU - Chiang, Yung-Hsiao

AU - Chen, Kai-Yun

PY - 2018/11/17

Y1 - 2018/11/17

N2 - Mild traumatic brain injury (mTBI) constitutes 75 ∼ 90% of all TBI cases and causes various physical, cognitive, emotional, and other psychological symptoms. Nogo receptor 1 (NgR1) is a regulator of structural brain plasticity during development and in adulthood. Here, we used mice that, in the absence of doxycycline, overexpress NgR1 in forebrain neurons (MemoFlex) to determine the role of NgR1 in recovery from mTBI with respect to balance, cognition, memory, and emotion. We compared wild-type (WT), MemoFlex, and MemoFlex + doxycycline mice to the same three groups subjected to mTBI. mTBI was induced by a controlled 30-g weight drop. We found that inability to downregulate NgR1 significantly impairs recovery from mTBI-induced impairments. When the NgR1 transgene was turned off, recovery was similar to that of WT mice. The results suggest that the ability to regulate NgR1 signaling is needed for optimal recovery of motor coordination and balance, spatial memory, cognition, and emotional functions after mTBI.

AB - Mild traumatic brain injury (mTBI) constitutes 75 ∼ 90% of all TBI cases and causes various physical, cognitive, emotional, and other psychological symptoms. Nogo receptor 1 (NgR1) is a regulator of structural brain plasticity during development and in adulthood. Here, we used mice that, in the absence of doxycycline, overexpress NgR1 in forebrain neurons (MemoFlex) to determine the role of NgR1 in recovery from mTBI with respect to balance, cognition, memory, and emotion. We compared wild-type (WT), MemoFlex, and MemoFlex + doxycycline mice to the same three groups subjected to mTBI. mTBI was induced by a controlled 30-g weight drop. We found that inability to downregulate NgR1 significantly impairs recovery from mTBI-induced impairments. When the NgR1 transgene was turned off, recovery was similar to that of WT mice. The results suggest that the ability to regulate NgR1 signaling is needed for optimal recovery of motor coordination and balance, spatial memory, cognition, and emotional functions after mTBI.

U2 - 10.1089/neu.2018.5949

DO - 10.1089/neu.2018.5949

M3 - Article

C2 - 30226403

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

ER -