Role of moxifloxacin for the treatment of commmunity-acquired complicated intra-abdominal infections in Taiwan

Yeu Jun Lau, Yen Hsu Chen, Ching Tai Huang, Wen Sen Lee, Cheng Yi Liu, Jien Wei Liu, Hsiao Dong Liu, Yuarn Jang Lee, Chao Wen Chen, Wen Chien Ko, Po Ren Hsueh

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

Complicated intra-abdominal infections (cIAIs) are common yet serious infections that can potentially lead to substantial morbidity and morbidity. As an essential adjunct to source control, the goals of antimicrobial therapy are to promote patient recovery, reduce recurrence risk, and prevent antimicrobial resistance. The current international guidelines on the empirical treatment of community-acquired complicated IAIs were published by the Infectious Diseases Society of America (IDSA) and Surgical Infections Society (SIS) in 2010. These guidelines all recommend the use of a fluoroquinolone (ciprofloxacin or levofloxacin) plus metronidazole for mild-to-moderate- and high-severity cases. Moxifloxacin monotherapy is recommended by the current IDSA/SIS guidelines for the treatment of mild-to-moderate complicated IAIs. Moxifloxacin has demonstrated a broad spectrum coverage of both aerobic and anaerobic pathogens, good tissue penetration into the gastrointestinal tract, and a good tolerability profile. Clinical data have demonstrated that moxifloxacin is at least as effective as other standard therapeutic regimens recommended by current clinical guidelines. Due to the high rates of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and fluoroquinolone-resistant Enterobacteriaceae among isolates causing community-acquired IAIs in Asia, any fluoroquinolones (including moxifloxacin) are not recommended as drugs of choice for the empirical treatment of community-acquired IAIs, particularly in countries (China, India, Thailand, and Vietnam) with fluoroquinolone resistance rates among Escherichia coli isolates of >20%. Given the low rates of fluoroquinolone-resistant (
原文英語
頁(從 - 到)1-6
頁數6
期刊Journal of Microbiology, Immunology and Infection
45
發行號1
DOIs
出版狀態已發佈 - 二月 2012

指紋

Intraabdominal Infections
Fluoroquinolones
Taiwan
Guidelines
Enterobacteriaceae
Infection
Morbidity
Therapeutics
Levofloxacin
Vietnam
Metronidazole
Thailand
Ciprofloxacin
Communicable Diseases
Gastrointestinal Tract
India
China
moxifloxacin
Escherichia coli
Recurrence

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Infectious Diseases

引用此文

Role of moxifloxacin for the treatment of commmunity-acquired complicated intra-abdominal infections in Taiwan. / Lau, Yeu Jun; Chen, Yen Hsu; Huang, Ching Tai; Lee, Wen Sen; Liu, Cheng Yi; Liu, Jien Wei; Liu, Hsiao Dong; Lee, Yuarn Jang; Chen, Chao Wen; Ko, Wen Chien; Hsueh, Po Ren.

於: Journal of Microbiology, Immunology and Infection, 卷 45, 編號 1, 02.2012, p. 1-6.

研究成果: 雜誌貢獻文章

Lau, Yeu Jun ; Chen, Yen Hsu ; Huang, Ching Tai ; Lee, Wen Sen ; Liu, Cheng Yi ; Liu, Jien Wei ; Liu, Hsiao Dong ; Lee, Yuarn Jang ; Chen, Chao Wen ; Ko, Wen Chien ; Hsueh, Po Ren. / Role of moxifloxacin for the treatment of commmunity-acquired complicated intra-abdominal infections in Taiwan. 於: Journal of Microbiology, Immunology and Infection. 2012 ; 卷 45, 編號 1. 頁 1-6.
@article{a7c00662f8d1476cb4884808a860a3a7,
title = "Role of moxifloxacin for the treatment of commmunity-acquired complicated intra-abdominal infections in Taiwan",
abstract = "Complicated intra-abdominal infections (cIAIs) are common yet serious infections that can potentially lead to substantial morbidity and morbidity. As an essential adjunct to source control, the goals of antimicrobial therapy are to promote patient recovery, reduce recurrence risk, and prevent antimicrobial resistance. The current international guidelines on the empirical treatment of community-acquired complicated IAIs were published by the Infectious Diseases Society of America (IDSA) and Surgical Infections Society (SIS) in 2010. These guidelines all recommend the use of a fluoroquinolone (ciprofloxacin or levofloxacin) plus metronidazole for mild-to-moderate- and high-severity cases. Moxifloxacin monotherapy is recommended by the current IDSA/SIS guidelines for the treatment of mild-to-moderate complicated IAIs. Moxifloxacin has demonstrated a broad spectrum coverage of both aerobic and anaerobic pathogens, good tissue penetration into the gastrointestinal tract, and a good tolerability profile. Clinical data have demonstrated that moxifloxacin is at least as effective as other standard therapeutic regimens recommended by current clinical guidelines. Due to the high rates of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and fluoroquinolone-resistant Enterobacteriaceae among isolates causing community-acquired IAIs in Asia, any fluoroquinolones (including moxifloxacin) are not recommended as drugs of choice for the empirical treatment of community-acquired IAIs, particularly in countries (China, India, Thailand, and Vietnam) with fluoroquinolone resistance rates among Escherichia coli isolates of >20{\%}. Given the low rates of fluoroquinolone-resistant (",
keywords = "Antimicrobial therapy, Complicated intra-abdominal infections, Fluoroquinolones, Moxifloxacin",
author = "Lau, {Yeu Jun} and Chen, {Yen Hsu} and Huang, {Ching Tai} and Lee, {Wen Sen} and Liu, {Cheng Yi} and Liu, {Jien Wei} and Liu, {Hsiao Dong} and Lee, {Yuarn Jang} and Chen, {Chao Wen} and Ko, {Wen Chien} and Hsueh, {Po Ren}",
year = "2012",
month = "2",
doi = "10.1016/j.jmii.2011.11.010",
language = "English",
volume = "45",
pages = "1--6",
journal = "Journal of Microbiology, Immunology and Infection",
issn = "0253-2662",
publisher = "Elsevier Taiwan LLC",
number = "1",

}

TY - JOUR

T1 - Role of moxifloxacin for the treatment of commmunity-acquired complicated intra-abdominal infections in Taiwan

AU - Lau, Yeu Jun

AU - Chen, Yen Hsu

AU - Huang, Ching Tai

AU - Lee, Wen Sen

AU - Liu, Cheng Yi

AU - Liu, Jien Wei

AU - Liu, Hsiao Dong

AU - Lee, Yuarn Jang

AU - Chen, Chao Wen

AU - Ko, Wen Chien

AU - Hsueh, Po Ren

PY - 2012/2

Y1 - 2012/2

N2 - Complicated intra-abdominal infections (cIAIs) are common yet serious infections that can potentially lead to substantial morbidity and morbidity. As an essential adjunct to source control, the goals of antimicrobial therapy are to promote patient recovery, reduce recurrence risk, and prevent antimicrobial resistance. The current international guidelines on the empirical treatment of community-acquired complicated IAIs were published by the Infectious Diseases Society of America (IDSA) and Surgical Infections Society (SIS) in 2010. These guidelines all recommend the use of a fluoroquinolone (ciprofloxacin or levofloxacin) plus metronidazole for mild-to-moderate- and high-severity cases. Moxifloxacin monotherapy is recommended by the current IDSA/SIS guidelines for the treatment of mild-to-moderate complicated IAIs. Moxifloxacin has demonstrated a broad spectrum coverage of both aerobic and anaerobic pathogens, good tissue penetration into the gastrointestinal tract, and a good tolerability profile. Clinical data have demonstrated that moxifloxacin is at least as effective as other standard therapeutic regimens recommended by current clinical guidelines. Due to the high rates of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and fluoroquinolone-resistant Enterobacteriaceae among isolates causing community-acquired IAIs in Asia, any fluoroquinolones (including moxifloxacin) are not recommended as drugs of choice for the empirical treatment of community-acquired IAIs, particularly in countries (China, India, Thailand, and Vietnam) with fluoroquinolone resistance rates among Escherichia coli isolates of >20%. Given the low rates of fluoroquinolone-resistant (

AB - Complicated intra-abdominal infections (cIAIs) are common yet serious infections that can potentially lead to substantial morbidity and morbidity. As an essential adjunct to source control, the goals of antimicrobial therapy are to promote patient recovery, reduce recurrence risk, and prevent antimicrobial resistance. The current international guidelines on the empirical treatment of community-acquired complicated IAIs were published by the Infectious Diseases Society of America (IDSA) and Surgical Infections Society (SIS) in 2010. These guidelines all recommend the use of a fluoroquinolone (ciprofloxacin or levofloxacin) plus metronidazole for mild-to-moderate- and high-severity cases. Moxifloxacin monotherapy is recommended by the current IDSA/SIS guidelines for the treatment of mild-to-moderate complicated IAIs. Moxifloxacin has demonstrated a broad spectrum coverage of both aerobic and anaerobic pathogens, good tissue penetration into the gastrointestinal tract, and a good tolerability profile. Clinical data have demonstrated that moxifloxacin is at least as effective as other standard therapeutic regimens recommended by current clinical guidelines. Due to the high rates of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and fluoroquinolone-resistant Enterobacteriaceae among isolates causing community-acquired IAIs in Asia, any fluoroquinolones (including moxifloxacin) are not recommended as drugs of choice for the empirical treatment of community-acquired IAIs, particularly in countries (China, India, Thailand, and Vietnam) with fluoroquinolone resistance rates among Escherichia coli isolates of >20%. Given the low rates of fluoroquinolone-resistant (

KW - Antimicrobial therapy

KW - Complicated intra-abdominal infections

KW - Fluoroquinolones

KW - Moxifloxacin

UR - http://www.scopus.com/inward/record.url?scp=84862827681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862827681&partnerID=8YFLogxK

U2 - 10.1016/j.jmii.2011.11.010

DO - 10.1016/j.jmii.2011.11.010

M3 - Article

C2 - 22244019

AN - SCOPUS:84862827681

VL - 45

SP - 1

EP - 6

JO - Journal of Microbiology, Immunology and Infection

JF - Journal of Microbiology, Immunology and Infection

SN - 0253-2662

IS - 1

ER -