Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer

C. W. Lin, S. W. Tseng, S. F. Yang, C. P. Ko, Chien-Huang Lin, L. H. Wei, M. H. Chien, Y. S. Hsieh

研究成果: 雜誌貢獻文章

27 引文 斯高帕斯(Scopus)

摘要

Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P
原文英語
頁(從 - 到)734-740
頁數7
期刊Oral Diseases
18
發行號8
DOIs
出版狀態已發佈 - 十一月 2012

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology

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