Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer

C. W. Lin, S. W. Tseng, S. F. Yang, C. P. Ko, Chien-Huang Lin, L. H. Wei, M. H. Chien, Y. S. Hsieh

研究成果: 雜誌貢獻 › 文章

26 引文 (Scopus)

摘要

Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P
原文英語
頁（從 - 到）734-740
頁數7
期刊Oral Diseases
卷18
發行號8
DOIs
出版狀態已發佈 - 十一月 2012

指紋

Mouth Neoplasms
Matrix Metalloproteinase 9
Squamous Cell Carcinoma
Matrix Metalloproteinases
Disease Progression
Neoplasms
Lipocalin-2

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology

引用此文

Lin, C. W., Tseng, S. W., Yang, S. F., Ko, C. P., Lin, C-H., Wei, L. H., ... Hsieh, Y. S. (2012). Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer. Oral Diseases, 18(8), 734-740. https://doi.org/10.1111/j.1601-0825.2012.01938.x

Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer. / Lin, C. W.; Tseng, S. W.; Yang, S. F.; Ko, C. P.; Lin, Chien-Huang; Wei, L. H.; Chien, M. H.; Hsieh, Y. S.

於: Oral Diseases, 卷 18, 編號 8, 11.2012, p. 734-740.

研究成果: 雜誌貢獻 › 文章

Lin, CW, Tseng, SW, Yang, SF, Ko, CP, Lin, C-H, Wei, LH, Chien, MH & Hsieh, YS 2012, 'Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer', Oral Diseases, 卷 18, 編號 8, 頁 734-740. https://doi.org/10.1111/j.1601-0825.2012.01938.x
Lin CW, Tseng SW, Yang SF, Ko CP, Lin C-H, Wei LH 等. Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer. Oral Diseases. 2012 11月;18(8):734-740. https://doi.org/10.1111/j.1601-0825.2012.01938.x
Lin, C. W. ; Tseng, S. W. ; Yang, S. F. ; Ko, C. P. ; Lin, Chien-Huang ; Wei, L. H. ; Chien, M. H. ; Hsieh, Y. S. / Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer. 於: Oral Diseases. 2012 ; 卷 18, 編號 8. 頁 734-740.
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abstract = "Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P",
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AB - Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P

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