Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats

I. Min Liu, Cheng Kuei Chang, Shiow Wen Juang, Dai Huang Kou, Yat Ching Tong, Kai Chun Cheng, Juei Tang Cheng

研究成果: 雜誌貢獻文章

13 引文 (Scopus)

摘要

The role of hyperglycaemia in the pathogenesis of hypotension in diabetic disorders was investigated using the changes in cardiac M 2-muscarinic receptor (M 2-mAChR) gene expression in type-1-like diabetic rats and cultured cardiomyocytes. Blood pressure was markedly decreased in diabetic rats following the intravenous injection of streptozotocin (STZ) for 8 weeks. Also, the baroreflex sensitivity (ΔHR/ΔBP), as measured by the changes in heart rate (ΔHR) and mean blood pressure (ΔBP) 1 min after the intravenous injection of phenylephrine (10 μg/kg), was significantly increased. Arecaidine propargyl ester (APE), a M 2-mAChR agonist produced a marked reduction in heart rate in these diabetic rats. Normalization of plasma glucose in diabetic rats using insulin (0.5 IU) or phlorizin (1 mg/kg) injection attenuated the blood pressure reduction and reversed the mRNA and protein levels of cardiac M 2-mAChR. A high concentration of glucose (20 mmol/l) directly influenced the increase in gene expression of M 2-mAChR in the H9c2 cardiac cell line. Hyperglycaemia induced an increase in cardiac M 2-mAChR gene expression, suggesting a role in the pathogenesis of hypotension in diabetic disorders.
原文英語
頁(從 - 到)292-300
頁數9
期刊International Journal of Experimental Pathology
89
發行號4
DOIs
出版狀態已發佈 - 八月 2008

指紋

Hyperglycemia
Hypotension
Blood Pressure
Heart Rate
Gene Expression
Intravenous Injections
Phlorhizin
Glucose
Baroreflex
Phenylephrine
Muscarinic Receptors
Streptozocin
Cardiac Myocytes
Insulin
Cell Line
Messenger RNA
Injections
Proteins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

引用此文

Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. / Liu, I. Min; Chang, Cheng Kuei; Juang, Shiow Wen; Kou, Dai Huang; Tong, Yat Ching; Cheng, Kai Chun; Cheng, Juei Tang.

於: International Journal of Experimental Pathology, 卷 89, 編號 4, 08.2008, p. 292-300.

研究成果: 雜誌貢獻文章

Liu, I. Min ; Chang, Cheng Kuei ; Juang, Shiow Wen ; Kou, Dai Huang ; Tong, Yat Ching ; Cheng, Kai Chun ; Cheng, Juei Tang. / Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. 於: International Journal of Experimental Pathology. 2008 ; 卷 89, 編號 4. 頁 292-300.
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