摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 292-300 |
| 頁數 | 9 |
| 期刊 | International Journal of Experimental Pathology |
| 卷 | 89 |
| 發行號 | 4 |
| DOIs | |
| 出版狀態 | 已發佈 - 八月 2008 |
指紋
ASJC Scopus subject areas
- Pathology and Forensic Medicine
引用此文
Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. / Liu, I. Min; Chang, Cheng Kuei; Juang, Shiow Wen; Kou, Dai Huang; Tong, Yat Ching; Cheng, Kai Chun; Cheng, Juei Tang.
於: International Journal of Experimental Pathology, 卷 89, 編號 4, 08.2008, p. 292-300.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats
AU - Liu, I. Min
AU - Chang, Cheng Kuei
AU - Juang, Shiow Wen
AU - Kou, Dai Huang
AU - Tong, Yat Ching
AU - Cheng, Kai Chun
AU - Cheng, Juei Tang
PY - 2008/8
Y1 - 2008/8
N2 - The role of hyperglycaemia in the pathogenesis of hypotension in diabetic disorders was investigated using the changes in cardiac M 2-muscarinic receptor (M 2-mAChR) gene expression in type-1-like diabetic rats and cultured cardiomyocytes. Blood pressure was markedly decreased in diabetic rats following the intravenous injection of streptozotocin (STZ) for 8 weeks. Also, the baroreflex sensitivity (ΔHR/ΔBP), as measured by the changes in heart rate (ΔHR) and mean blood pressure (ΔBP) 1 min after the intravenous injection of phenylephrine (10 μg/kg), was significantly increased. Arecaidine propargyl ester (APE), a M 2-mAChR agonist produced a marked reduction in heart rate in these diabetic rats. Normalization of plasma glucose in diabetic rats using insulin (0.5 IU) or phlorizin (1 mg/kg) injection attenuated the blood pressure reduction and reversed the mRNA and protein levels of cardiac M 2-mAChR. A high concentration of glucose (20 mmol/l) directly influenced the increase in gene expression of M 2-mAChR in the H9c2 cardiac cell line. Hyperglycaemia induced an increase in cardiac M 2-mAChR gene expression, suggesting a role in the pathogenesis of hypotension in diabetic disorders.
AB - The role of hyperglycaemia in the pathogenesis of hypotension in diabetic disorders was investigated using the changes in cardiac M 2-muscarinic receptor (M 2-mAChR) gene expression in type-1-like diabetic rats and cultured cardiomyocytes. Blood pressure was markedly decreased in diabetic rats following the intravenous injection of streptozotocin (STZ) for 8 weeks. Also, the baroreflex sensitivity (ΔHR/ΔBP), as measured by the changes in heart rate (ΔHR) and mean blood pressure (ΔBP) 1 min after the intravenous injection of phenylephrine (10 μg/kg), was significantly increased. Arecaidine propargyl ester (APE), a M 2-mAChR agonist produced a marked reduction in heart rate in these diabetic rats. Normalization of plasma glucose in diabetic rats using insulin (0.5 IU) or phlorizin (1 mg/kg) injection attenuated the blood pressure reduction and reversed the mRNA and protein levels of cardiac M 2-mAChR. A high concentration of glucose (20 mmol/l) directly influenced the increase in gene expression of M 2-mAChR in the H9c2 cardiac cell line. Hyperglycaemia induced an increase in cardiac M 2-mAChR gene expression, suggesting a role in the pathogenesis of hypotension in diabetic disorders.
KW - Cardiac M -muscarinic receptor
KW - Diabetic rats
KW - Gene expression
KW - Hyperglycaemia
KW - Insulin
KW - Phlorizin
UR - http://www.scopus.com/inward/record.url?scp=47649123927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47649123927&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2613.2008.00595.x
DO - 10.1111/j.1365-2613.2008.00595.x
M3 - Article
VL - 89
SP - 292
EP - 300
JO - International Journal of Experimental Pathology
JF - International Journal of Experimental Pathology
SN - 0959-9673
IS - 4
ER -