Role of creatine phosphokinase in predicting acute renal failure in hypocalcemic exertional heat stroke

Shang Der Shieh, Yuh Feng Lin, Kuo Cheng Lu, Bi Lian Li, Pauling Chu, Tai Pin Shyh, Liang Kuang Diang

研究成果: 雜誌貢獻文章

19 引文 (Scopus)

摘要

Recruits frequently develop hypocalcemia in exertional heat stroke (ExHS) with rhabdomyolysis and acute renal failure (ARF) from intensive training. It usually indicated severe skeletal muscle damage. However, the relative risk of ARF in ExHS patients complicated with hypocalcemia was unknown. The present study was undertaken to evaluate the value of peak serum creatine phosphokinase (CPK) level in predicting ARF in ExHS patients with hypocalcemia. Sixty-eight army recruits with ExHS were hospitalized at the Tri-Service General Hospital, Taiwan: 17 with ARF and hypocalcemia (group A); 7 with ARF but without hypocalcemia (group B); 20 without ARF but with hypocalcemia (group C); and 24 without ARF or hypocalcemia (group D). In the 24 patients with ARF (groups A and B) the serum phosphate and peak CPK levels were significantly higher than in patients without ARF (groups C and D; p <0.001), serum calcium levels were also significantly lower in the former (p <0.001). In the 37 patients with hypocalcemia (groups A and C), the peak serum CPK levels were significantly higher than in those without hypocalcemia (groups B and D; p <0.001). There was a higher proportion of hypocalcemic patients with peak serum CPK levels greater than 10, 000 U/l among ARF compared with patients without ARF (χ2 = 12.48, p <0.001). In 24 patients with ARF, there was a negative correlation between serum Ca and peak CPK levels (t = 3.37, r = -0.58, p <0.01). However, a positive correlation was found between serum creatinine and peak serum CPK levels in 37 patients with hypocalcemia (t = 2.47, r = 0.39, p <0.02). In conclusion, hypocalcemia was found in 37/68 (54.4%) of ExHS patients. Peak serum CPK over 10, 000 U/l increases the tendency of developing ARF; furthermore, it is unequivocally useful in predicting ARF in hypocalcemic ExHS patients.

原文英語
頁(從 - 到)252-258
頁數7
期刊American Journal of Nephrology
12
發行號4
DOIs
出版狀態已發佈 - 1992
對外發佈Yes

指紋

Heat Stroke
Creatine Kinase
Acute Kidney Injury
Hypocalcemia
Serum
Rhabdomyolysis
Taiwan

ASJC Scopus subject areas

  • Nephrology

引用此文

Role of creatine phosphokinase in predicting acute renal failure in hypocalcemic exertional heat stroke. / Shieh, Shang Der; Lin, Yuh Feng; Lu, Kuo Cheng; Li, Bi Lian; Chu, Pauling; Shyh, Tai Pin; Diang, Liang Kuang.

於: American Journal of Nephrology, 卷 12, 編號 4, 1992, p. 252-258.

研究成果: 雜誌貢獻文章

Shieh, Shang Der ; Lin, Yuh Feng ; Lu, Kuo Cheng ; Li, Bi Lian ; Chu, Pauling ; Shyh, Tai Pin ; Diang, Liang Kuang. / Role of creatine phosphokinase in predicting acute renal failure in hypocalcemic exertional heat stroke. 於: American Journal of Nephrology. 1992 ; 卷 12, 編號 4. 頁 252-258.
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title = "Role of creatine phosphokinase in predicting acute renal failure in hypocalcemic exertional heat stroke",
abstract = "Recruits frequently develop hypocalcemia in exertional heat stroke (ExHS) with rhabdomyolysis and acute renal failure (ARF) from intensive training. It usually indicated severe skeletal muscle damage. However, the relative risk of ARF in ExHS patients complicated with hypocalcemia was unknown. The present study was undertaken to evaluate the value of peak serum creatine phosphokinase (CPK) level in predicting ARF in ExHS patients with hypocalcemia. Sixty-eight army recruits with ExHS were hospitalized at the Tri-Service General Hospital, Taiwan: 17 with ARF and hypocalcemia (group A); 7 with ARF but without hypocalcemia (group B); 20 without ARF but with hypocalcemia (group C); and 24 without ARF or hypocalcemia (group D). In the 24 patients with ARF (groups A and B) the serum phosphate and peak CPK levels were significantly higher than in patients without ARF (groups C and D; p <0.001), serum calcium levels were also significantly lower in the former (p <0.001). In the 37 patients with hypocalcemia (groups A and C), the peak serum CPK levels were significantly higher than in those without hypocalcemia (groups B and D; p <0.001). There was a higher proportion of hypocalcemic patients with peak serum CPK levels greater than 10, 000 U/l among ARF compared with patients without ARF (χ2 = 12.48, p <0.001). In 24 patients with ARF, there was a negative correlation between serum Ca and peak CPK levels (t = 3.37, r = -0.58, p <0.01). However, a positive correlation was found between serum creatinine and peak serum CPK levels in 37 patients with hypocalcemia (t = 2.47, r = 0.39, p <0.02). In conclusion, hypocalcemia was found in 37/68 (54.4{\%}) of ExHS patients. Peak serum CPK over 10, 000 U/l increases the tendency of developing ARF; furthermore, it is unequivocally useful in predicting ARF in hypocalcemic ExHS patients.",
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AU - Shieh, Shang Der

AU - Lin, Yuh Feng

AU - Lu, Kuo Cheng

AU - Li, Bi Lian

AU - Chu, Pauling

AU - Shyh, Tai Pin

AU - Diang, Liang Kuang

PY - 1992

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N2 - Recruits frequently develop hypocalcemia in exertional heat stroke (ExHS) with rhabdomyolysis and acute renal failure (ARF) from intensive training. It usually indicated severe skeletal muscle damage. However, the relative risk of ARF in ExHS patients complicated with hypocalcemia was unknown. The present study was undertaken to evaluate the value of peak serum creatine phosphokinase (CPK) level in predicting ARF in ExHS patients with hypocalcemia. Sixty-eight army recruits with ExHS were hospitalized at the Tri-Service General Hospital, Taiwan: 17 with ARF and hypocalcemia (group A); 7 with ARF but without hypocalcemia (group B); 20 without ARF but with hypocalcemia (group C); and 24 without ARF or hypocalcemia (group D). In the 24 patients with ARF (groups A and B) the serum phosphate and peak CPK levels were significantly higher than in patients without ARF (groups C and D; p <0.001), serum calcium levels were also significantly lower in the former (p <0.001). In the 37 patients with hypocalcemia (groups A and C), the peak serum CPK levels were significantly higher than in those without hypocalcemia (groups B and D; p <0.001). There was a higher proportion of hypocalcemic patients with peak serum CPK levels greater than 10, 000 U/l among ARF compared with patients without ARF (χ2 = 12.48, p <0.001). In 24 patients with ARF, there was a negative correlation between serum Ca and peak CPK levels (t = 3.37, r = -0.58, p <0.01). However, a positive correlation was found between serum creatinine and peak serum CPK levels in 37 patients with hypocalcemia (t = 2.47, r = 0.39, p <0.02). In conclusion, hypocalcemia was found in 37/68 (54.4%) of ExHS patients. Peak serum CPK over 10, 000 U/l increases the tendency of developing ARF; furthermore, it is unequivocally useful in predicting ARF in hypocalcemic ExHS patients.

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KW - Creatine phosphokinase

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KW - Rhabdomyolysis

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