Role of Bladder Capacity in Assessing the Effectiveness of Antimuscarinic Agents on Nocturia in Patients with Overactive Bladders

Shang Jen Chang, Stephen S D Yang, Yao Chou Tsai, Chia Chang Wu, Cheng Hsing Hsieh

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)


Objective: The aim of this study was to evaluate the effectiveness of oxybutynin in the treatment of nocturia in patients with overactive bladders (OAB) and to assess predictive factors for the responses to oxybutynin. Patients and Methods: Patients with symptoms of OAB and nocturia for more than 3 months were enrolled. A 2.5 mg dose of oxybutynin was given twice daily for 1 week after a baseline study that included a self-administered nocturia questionnaire, uroflowmetry, and frequency/volume chart. Outcome analysis included changes in nocturia episodes, uroflowmetry, and post-void residual urine. Patients were stratified according to a nocturia index (Ni), nocturnal polyuria index (NPi), and nocturnal bladder capacity index (NBCi). Results: A total of 59 patients were eligible for analysis. After 1 week of treatment with oxybutynin, the mean number of nocturia episodes had reduced from 2.7 ± 1.3 to 2.3 ± 1.1 (p <0.01). There were no statistically significant differences in the mean reduction of nocturia episodes between the subgroup of patients with NPi ≤ 0.35 and those with NPi > 0.35 (-0.4 vs. -0.3, p = 0.34, ANCOVA). Reduction in number of nocturia episodes was more significant in patients with Ni ≤ 1.5 than in those with Ni > 1.5 (-0.9 vs. -0.2, p = 0.03, ANCOVA), and in patients with NBCi > 2 than in those with NBCi ≤ 2 (-1.1 vs. -0.2, p = 0.01, ANCOVA). Conclusion: Ni and NBCi are good predicting factors for the effects of antimuscarinic agents on nocturia in patients with OAB.

頁(從 - 到)304-308
期刊Tzu Chi Medical Journal
出版狀態已發佈 - 十二月 2008


ASJC Scopus subject areas

  • Medicine(all)