RNAMST: Efficient and flexible approach for identifying RNA structural homologs

Tzu H. Chang, Hsien D. Huang, Tzu Neng Chuang, Dray Ming Shien, Jorng Tzong Horng

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

RNA molecules fold into characteristic secondary structures for their diverse functional activities such as post-translational regulation of gene expression. Searching homologs of a pre-defined RNA structural motif, which may be a known functional element or a putative RNA structural motif, can provide useful information for deciphering RNA regulatory mechanisms. Since searching for the RNA structural homologs among the numerous RNA sequences is extremely time-consuming, this work develops a data preprocessing strategy to enhance the search efficiency and presents RNAMST, which is an efficient and flexible web server for rapidly identifying homologs of a pre-defined RNA structural motif among numerous RNA sequences. Intuitive user interface are provided on the web server to facilitate the predictive analysis. By comparing the proposed web server to other tools developed previously, RNAMST performs remarkably more efficiently and provides more effective and flexible functions. RNAMST is now available on the web at http://bioinfo.csie.ncu.edu.tw/~rnamst/.

原文英語
期刊Nucleic Acids Research
34
發行號WEB. SERV. ISS.
DOIs
出版狀態已發佈 - 7月 2006
對外發佈

ASJC Scopus subject areas

  • 遺傳學

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