Risks of posterior segment ocular ischaemic events in patients with systemic lupus erythematosus: a population-based cohort study in Taiwan

Yi Ran Chiou, Yu Sheng Chang, Chin Fang Su, Tzu Hao Li, Chien Chih Lai, De Kuang Hwang, Fang Yi Wu, Yu Fan Chang

研究成果: 雜誌貢獻文章同行評審

摘要

Backgroud/Aim: Ocular involvement in systemic lupus erythematosus (SLE) is often primarily recognised by ophthalmologists rather than internists. This study aims to investigate the incidence and risk factors for the occurrence of posterior ocular ischaemic events (OIE), including retinal vein occlusion (RVO), retinal artery occlusion (RAO) and ischaemic optic neuropathy (ION), in patients with SLE. Methods: A national database in Taiwan was used to identify 24 472 patients newly diagnosed with SLE and 244 720 age-matched and sex-matched controls between 1997 and 2012. New occurrences of OIE and confounding factors were recorded. The Kaplan-Meier method was used to compare the risk of OIE between the two groups. Fixed effect models were applied to evaluate the risk factors for OIE. Results: The mean age was 36.24±15.82 years and women accounted for 88.4%. Patients with SLE had significantly increased risk of overall OIE (HR 3.89, 95% CI 3.36 to 4.50, p
原文英語
文章編號321653
期刊British Journal of Ophthalmology
DOIs
出版狀態接受/付印 - 2022

ASJC Scopus subject areas

  • 眼科
  • 感覺系統
  • 細胞與分子神經科學

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