Risks of all-cause mortality and major kidney events in patients with new-onset primary open-angle glaucoma: A nationwide long-term cohort study in Taiwan

Chu Lin Chou, Tsung Cheng Hsieh, Jin Shuen Chen, Te Chao Fang

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Objective Cardiovascular risk factors are associated with primary open-angle glaucoma (POAG) in the general population. However, long-term mortality and major kidney events in patients with new-onset POAG remain unclear. Methods Using the Taiwan National Health Insurance Research Database between 1997 and 2011, 15 185 patients with a new diagnosis of POAG were enrolled and propensity score matched (1:1) with 15 185 patients without ocular disorders (WODs). All-cause mortality and major kidney events were analysed by a multivariate Cox proportional hazards regression model and a competing risk regression model. Results The risk of all-cause mortality was significantly higher in patients with new-onset POAG than in those WODs (adjusted HR (aHR) 2.11, 95% CI 1.76 to 2.54; p<0.001). Patients with POAG had higher risks of acute renal failure (ARF) (competing risk aHR 2.58, 95% CI 1.88 to 3.55; p<0.001) and end-stage renal disease (ESRD) (competing risk aHR 4.84, 95% CI 3.02 to 7.77; p<0.001) than those WODs. Conclusions Our data demonstrate that POAG is a risk of all-cause mortality, ARF and ESRD, thus needing to notice mortality and major kidney events in patients with new-onset POAG.
原文英語
文章編號e021270
頁(從 - 到)e021270
期刊BMJ Open
8
發行號3
DOIs
出版狀態已發佈 - 三月 1 2018

指紋

Taiwan
Cohort Studies
Kidney
Mortality
Acute Kidney Injury
Chronic Kidney Failure
Propensity Score
National Health Programs
Primary Open Angle Glaucoma
Proportional Hazards Models
Databases
Research
Population

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Risks of all-cause mortality and major kidney events in patients with new-onset primary open-angle glaucoma : A nationwide long-term cohort study in Taiwan. / Chou, Chu Lin; Hsieh, Tsung Cheng; Chen, Jin Shuen; Fang, Te Chao.

於: BMJ Open, 卷 8, 編號 3, e021270, 01.03.2018, p. e021270.

研究成果: 雜誌貢獻文章

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title = "Risks of all-cause mortality and major kidney events in patients with new-onset primary open-angle glaucoma: A nationwide long-term cohort study in Taiwan",
abstract = "Objective Cardiovascular risk factors are associated with primary open-angle glaucoma (POAG) in the general population. However, long-term mortality and major kidney events in patients with new-onset POAG remain unclear. Methods Using the Taiwan National Health Insurance Research Database between 1997 and 2011, 15 185 patients with a new diagnosis of POAG were enrolled and propensity score matched (1:1) with 15 185 patients without ocular disorders (WODs). All-cause mortality and major kidney events were analysed by a multivariate Cox proportional hazards regression model and a competing risk regression model. Results The risk of all-cause mortality was significantly higher in patients with new-onset POAG than in those WODs (adjusted HR (aHR) 2.11, 95{\%} CI 1.76 to 2.54; p<0.001). Patients with POAG had higher risks of acute renal failure (ARF) (competing risk aHR 2.58, 95{\%} CI 1.88 to 3.55; p<0.001) and end-stage renal disease (ESRD) (competing risk aHR 4.84, 95{\%} CI 3.02 to 7.77; p<0.001) than those WODs. Conclusions Our data demonstrate that POAG is a risk of all-cause mortality, ARF and ESRD, thus needing to notice mortality and major kidney events in patients with new-onset POAG.",
keywords = "acute renal failure, end-stage renal disease, mortality, primary open-angle glaucoma",
author = "Chou, {Chu Lin} and Hsieh, {Tsung Cheng} and Chen, {Jin Shuen} and Fang, {Te Chao}",
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T1 - Risks of all-cause mortality and major kidney events in patients with new-onset primary open-angle glaucoma

T2 - A nationwide long-term cohort study in Taiwan

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AU - Hsieh, Tsung Cheng

AU - Chen, Jin Shuen

AU - Fang, Te Chao

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Objective Cardiovascular risk factors are associated with primary open-angle glaucoma (POAG) in the general population. However, long-term mortality and major kidney events in patients with new-onset POAG remain unclear. Methods Using the Taiwan National Health Insurance Research Database between 1997 and 2011, 15 185 patients with a new diagnosis of POAG were enrolled and propensity score matched (1:1) with 15 185 patients without ocular disorders (WODs). All-cause mortality and major kidney events were analysed by a multivariate Cox proportional hazards regression model and a competing risk regression model. Results The risk of all-cause mortality was significantly higher in patients with new-onset POAG than in those WODs (adjusted HR (aHR) 2.11, 95% CI 1.76 to 2.54; p<0.001). Patients with POAG had higher risks of acute renal failure (ARF) (competing risk aHR 2.58, 95% CI 1.88 to 3.55; p<0.001) and end-stage renal disease (ESRD) (competing risk aHR 4.84, 95% CI 3.02 to 7.77; p<0.001) than those WODs. Conclusions Our data demonstrate that POAG is a risk of all-cause mortality, ARF and ESRD, thus needing to notice mortality and major kidney events in patients with new-onset POAG.

AB - Objective Cardiovascular risk factors are associated with primary open-angle glaucoma (POAG) in the general population. However, long-term mortality and major kidney events in patients with new-onset POAG remain unclear. Methods Using the Taiwan National Health Insurance Research Database between 1997 and 2011, 15 185 patients with a new diagnosis of POAG were enrolled and propensity score matched (1:1) with 15 185 patients without ocular disorders (WODs). All-cause mortality and major kidney events were analysed by a multivariate Cox proportional hazards regression model and a competing risk regression model. Results The risk of all-cause mortality was significantly higher in patients with new-onset POAG than in those WODs (adjusted HR (aHR) 2.11, 95% CI 1.76 to 2.54; p<0.001). Patients with POAG had higher risks of acute renal failure (ARF) (competing risk aHR 2.58, 95% CI 1.88 to 3.55; p<0.001) and end-stage renal disease (ESRD) (competing risk aHR 4.84, 95% CI 3.02 to 7.77; p<0.001) than those WODs. Conclusions Our data demonstrate that POAG is a risk of all-cause mortality, ARF and ESRD, thus needing to notice mortality and major kidney events in patients with new-onset POAG.

KW - acute renal failure

KW - end-stage renal disease

KW - mortality

KW - primary open-angle glaucoma

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