Risk of stroke among patients with rhinosinusitis: A population-based study in Taiwan

Chin Wen Wu, Pin Zhir Chao, Wen Rui Hao, Tsan Hon Liou, Hui Wen Lin

研究成果: 雜誌貢獻文章同行評審

21 引文 斯高帕斯(Scopus)


Background: Research has found evidence that chronic inflammation may promote atherosclerotic disease. The purpose of this study was to test the hypothesis that rhinosinusitis is a risk factor for stroke. Methods: This prospective cohort study comprised patients recorded on the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005) who had received a diagnosis of rhinosinusitis (n = 53,653) between January 1, 2004 and December 31, 2005. A control group (1:4) drawn from the same database was matched for age and gender (n = 214,624). Each patient was followed up using data entered until the end of 2006. Cox proportional hazard regressions were performed to evaluate the hazard ratios (HRs) after adjusting for potential confounding factors. Results: We found that patients with rhinosinusitis were more likely to suffer strokes than the control population, after adjusting for potential confounders (adjusted HR, 1.39; 95% confidence interval [CI], 1.28-1.50). The HR of stroke was 1.39 (95% CI, 1.28-1.51) for acute sinusitis patients, and 1.34 (95% CI, 1.04-1.74) for chronic sinusitis patients. Conclusion: Both acute and chronic sinusitis are risk factors or markers for stroke that is independent of traditional stroke risk factors. Further research in this important area of epidemiology is warranted.

頁(從 - 到)278-282
期刊American Journal of Rhinology and Allergy
出版狀態已發佈 - 7月 2012

ASJC Scopus subject areas

  • 耳鼻咽喉科
  • 免疫學和過敏


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