Risk of obstructive sleep apnea in patients with Sjögren syndrome and Behçet’s disease: a nationwide, population-based cohort study

Tsai Chu Yeh, Wei Sheng Chen, Yu Sheng Chang, Yi Chun Lin, Yi Hsiang Huang, Chang Youh Tsai, Jin Hua Chen, Chi Ching Chang

研究成果: 雜誌貢獻文章

摘要

Purpose: Patients with obstructive sleep apnea (OSA) have a higher risk of Behçet’s disease (BD) and Sjögren syndrome (SS). However, the bidirectional relationship between these autoimmune diseases and OSA is unclear. We investigated the relationship between autoimmune diseases (SS and BD) and OSA. Methods: SS and BD patients were identified through the Taiwan National Health Insurance Research Database from 2002 to 2012. Patients with SS or BD were matched according to age and sex with a control group in a ratio of 1:4. The study included 12,926 patients with SS and 51,704 non-SS controls. Similarly, 1221 patients with BD were matched with 4884 non-BD controls. We used a Cox regression model, stratified by age, gender, and comorbidities, to assess the risk of OSA. Results: OSA was diagnosed in 0.61% of the SS cohort and 1.23% of the BD cohort. The higher overall risk for OSA was observed significantly in patients with SS than in controls (adjusted hazard ratio [HR] = 2.48, 95% confidence interval [CI] = 1.89–3.24). The higher risk was also observed significantly in BD patients than in controls (HR = 1.99, 95% CI = 1.06–3.72). Furthermore, men with SS or BD exhibited HR of 2.62 (95% CI 1.89 to 3.62) and 6.40 (95% CI 2.96 to 13.84) for developing OSA, respectively. Conclusion: Risk of OSA was significantly elevated in SS or BD patients compared with controls. Further study is warranted to elucidate underlying mechanisms.

原文英語
頁(從 - 到)1199-1205
頁數7
期刊Sleep and Breathing
24
發行號3
DOIs
出版狀態接受/付印 - 2020

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology

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