摘要

Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study cohort comprised patients who had received a recorded diagnosis of rhinosinusitis (N = 52,930) between January 1, 2004 and December 31, 2004. The comparison group consisted of patients who had not received a rhinosinusitis diagnosis, and who were matched for age and sex with the study group at a ratio of 4 controls to 1 study patient (1:4) (N = 211,720). Each patient's condition was followed using database entries until the end of 2006. Cox proportional hazard regressions were used to evaluate the 3-year MI-free survival rates, after adjusting for known confounding factors. We found that patients with rhinosinusitis were more likely than the control group to have MI, after adjusting for potential confounders [adjusted hazard ratio (HR), 1.84; 95% confidence interval (CI), 1.44 ∼ 2.40]. Of the total 264 650 patients, 290 experienced MI during the 3-year follow-up period, including 8 acute sinusitis patients, 77 chronic sinusitis patients, and 205 control patients. The incidence rate of MI was 6.19 (95% CI 5.01-7.65) per 10,000 person-years for rhinosinusitis patients, compared to 3.51 (95% CI, 3.06-4.02) for the control patients. From this study, rhinosinusitis may be associated with MI. Further research in this important area of public health is warranted.

原文英語
頁(從 - 到)263-268
頁數6
期刊Atherosclerosis
226
發行號1
DOIs
出版狀態已發佈 - 一月 2013

指紋

Myocardial Infarction
Sinusitis
Confidence Intervals
Databases
Health Insurance
Taiwan
Research
Atherosclerosis
Cohort Studies
Survival Rate
Public Health
Inflammation
Control Groups
Incidence
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

Risk of myocardial infarction in patients with rhinosinusitis. / Hao, Wen Rui; Lin, Hui Wen; Chao, Pin Zhir; Wu, Chin Wen; Yen, Tze Hsun; Liu, Ju Chi; Liou, Tsan Hon.

於: Atherosclerosis, 卷 226, 編號 1, 01.2013, p. 263-268.

研究成果: 雜誌貢獻文章

Hao, Wen Rui ; Lin, Hui Wen ; Chao, Pin Zhir ; Wu, Chin Wen ; Yen, Tze Hsun ; Liu, Ju Chi ; Liou, Tsan Hon. / Risk of myocardial infarction in patients with rhinosinusitis. 於: Atherosclerosis. 2013 ; 卷 226, 編號 1. 頁 263-268.
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abstract = "Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study cohort comprised patients who had received a recorded diagnosis of rhinosinusitis (N = 52,930) between January 1, 2004 and December 31, 2004. The comparison group consisted of patients who had not received a rhinosinusitis diagnosis, and who were matched for age and sex with the study group at a ratio of 4 controls to 1 study patient (1:4) (N = 211,720). Each patient's condition was followed using database entries until the end of 2006. Cox proportional hazard regressions were used to evaluate the 3-year MI-free survival rates, after adjusting for known confounding factors. We found that patients with rhinosinusitis were more likely than the control group to have MI, after adjusting for potential confounders [adjusted hazard ratio (HR), 1.84; 95{\%} confidence interval (CI), 1.44 ∼ 2.40]. Of the total 264 650 patients, 290 experienced MI during the 3-year follow-up period, including 8 acute sinusitis patients, 77 chronic sinusitis patients, and 205 control patients. The incidence rate of MI was 6.19 (95{\%} CI 5.01-7.65) per 10,000 person-years for rhinosinusitis patients, compared to 3.51 (95{\%} CI, 3.06-4.02) for the control patients. From this study, rhinosinusitis may be associated with MI. Further research in this important area of public health is warranted.",
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AU - Hao, Wen Rui

AU - Lin, Hui Wen

AU - Chao, Pin Zhir

AU - Wu, Chin Wen

AU - Yen, Tze Hsun

AU - Liu, Ju Chi

AU - Liou, Tsan Hon

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AB - Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study cohort comprised patients who had received a recorded diagnosis of rhinosinusitis (N = 52,930) between January 1, 2004 and December 31, 2004. The comparison group consisted of patients who had not received a rhinosinusitis diagnosis, and who were matched for age and sex with the study group at a ratio of 4 controls to 1 study patient (1:4) (N = 211,720). Each patient's condition was followed using database entries until the end of 2006. Cox proportional hazard regressions were used to evaluate the 3-year MI-free survival rates, after adjusting for known confounding factors. We found that patients with rhinosinusitis were more likely than the control group to have MI, after adjusting for potential confounders [adjusted hazard ratio (HR), 1.84; 95% confidence interval (CI), 1.44 ∼ 2.40]. Of the total 264 650 patients, 290 experienced MI during the 3-year follow-up period, including 8 acute sinusitis patients, 77 chronic sinusitis patients, and 205 control patients. The incidence rate of MI was 6.19 (95% CI 5.01-7.65) per 10,000 person-years for rhinosinusitis patients, compared to 3.51 (95% CI, 3.06-4.02) for the control patients. From this study, rhinosinusitis may be associated with MI. Further research in this important area of public health is warranted.

KW - Epidemiology

KW - Incidence

KW - MI

KW - Rhinosinusitis

KW - Risk factors

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