Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer

William Wang Yu Su, Shu Lin Chuang, Amy Ming Fang Yen, Sam Li Sheng Chen, Jean Ching Yuan Fann, Sherry Yueh Hsia Chiu, Han Mo Chiu, Chiu Wen Su, Chen Yang Hsu, Mu Kuan Chen, Hsiu Hsi Chen, Cheng Ping Wang, Yi Chia Lee

研究成果: 雜誌貢獻 › 文章

1 引文 (Scopus)

摘要

Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.
原文英語
頁（從 - 到）1067-1075
頁數9
期刊Oral Diseases
卷25
發行號4
DOIs
出版狀態已發佈 - 五月 1 2019

指紋

Hypopharyngeal Neoplasms
Second Primary Neoplasms
Mouth Neoplasms
Esophageal Neoplasms
Hypopharynx
Esophagus
Confidence Intervals
Oropharyngeal Neoplasms
Lip Neoplasms
Hard Palate
Mouth Floor
Tongue Neoplasms
Mass Screening
Gingiva
Taiwan
Tobacco Products

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

引用此文

Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer. / Su, William Wang Yu; Chuang, Shu Lin; Yen, Amy Ming Fang; Chen, Sam Li Sheng; Fann, Jean Ching Yuan; Chiu, Sherry Yueh Hsia; Chiu, Han Mo; Su, Chiu Wen; Hsu, Chen Yang; Chen, Mu Kuan; Chen, Hsiu Hsi; Wang, Cheng Ping; Lee, Yi Chia.

於: Oral Diseases, 卷 25, 編號 4, 01.05.2019, p. 1067-1075.

研究成果: 雜誌貢獻 › 文章

Su, WWY, Chuang, SL, Yen, AMF, Chen, SLS, Fann, JCY, Chiu, SYH, Chiu, HM, Su, CW, Hsu, CY, Chen, MK, Chen, HH, Wang, CP & Lee, YC 2019, 'Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer', Oral Diseases, 卷 25, 編號 4, 頁 1067-1075. https://doi.org/10.1111/odi.13080
Su WWY, Chuang SL, Yen AMF, Chen SLS, Fann JCY, Chiu SYH 等. Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer. Oral Diseases. 2019 5月 1;25(4):1067-1075. https://doi.org/10.1111/odi.13080
Su, William Wang Yu ; Chuang, Shu Lin ; Yen, Amy Ming Fang ; Chen, Sam Li Sheng ; Fann, Jean Ching Yuan ; Chiu, Sherry Yueh Hsia ; Chiu, Han Mo ; Su, Chiu Wen ; Hsu, Chen Yang ; Chen, Mu Kuan ; Chen, Hsiu Hsi ; Wang, Cheng Ping ; Lee, Yi Chia. / Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer. 於: Oral Diseases. 2019 ; 卷 25, 編號 4. 頁 1067-1075.
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abstract = "Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95{\%} confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95{\%} CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95{\%} CI: 2.67–55.15), and hard palate (aRR: 7.31, 95{\%} CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95{\%} CI: 0.89–15.17) or gum (aRR: 3.99, 95{\%} CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95{\%} CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.",
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author = "Su, {William Wang Yu} and Chuang, {Shu Lin} and Yen, {Amy Ming Fang} and Chen, {Sam Li Sheng} and Fann, {Jean Ching Yuan} and Chiu, {Sherry Yueh Hsia} and Chiu, {Han Mo} and Su, {Chiu Wen} and Hsu, {Chen Yang} and Chen, {Mu Kuan} and Chen, {Hsiu Hsi} and Wang, {Cheng Ping} and Lee, {Yi Chia}",
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T1 - Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer

AU - Su, William Wang Yu

AU - Chuang, Shu Lin

AU - Yen, Amy Ming Fang

AU - Chen, Sam Li Sheng

AU - Fann, Jean Ching Yuan

AU - Chiu, Sherry Yueh Hsia

AU - Chiu, Han Mo

AU - Su, Chiu Wen

AU - Hsu, Chen Yang

AU - Chen, Mu Kuan

AU - Chen, Hsiu Hsi

AU - Wang, Cheng Ping

AU - Lee, Yi Chia

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.

AB - Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.

KW - cancer screening

KW - esophageal cancer

KW - hypopharyngeal cancer

KW - oral/oropharyngeal cancer

KW - second primary cancer

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