Risk factors for liver abscess formation in patients with blunt hepatic injury after non-operative management

C. P. Hsu, S. Y. Wang, Y. P. Hsu, H. W. Chen, B. C. Lin, S. C. Kang, K. C. Yuan, E. H. Liu, I. M. Kuo, C. H. Liao, C. H. Ouyang, S. J. Yang

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

Purpose: To identify risk factors for liver abscess formation in patients with blunt hepatic injury who underwent non-operative management (NOM).

Methods: From January 2004 to October 2008, retrospective data were collected from a single level I trauma center. Clinical data, hospital course, and outcome were all extracted from patient medical records for further analysis.

Results: A total of 358 patients were enrolled for analysis. There were 13 patients with liver abscess after blunt hepatic injury. Patients with abscess had a significant increase in glutamic oxaloacetic transaminase (GOT, p = 0.006) and glutamic pyruvic transaminase (GPT, p < 0.0001), and a decrease in arterial blood pH (p = 0.023) compared to patients without abscess in the univariate analyses. In addition, high-grade hepatic injury and transarterial embolization (TAE, p < 0.001) were also risk factors for liver abscess formation. Five factors (GOT, GPT, pH level in the arterial blood sample, TAE, and high-grade hepatic injury) were included in the multivariate analysis. TAE, high-grade hepatic injury, and GPT level were statistically significant. The odds ratios of TAE and high-grade hepatic injury were 15.41 and 16.08, respectively. A receiver operating characteristic (ROC) analysis was used for GPT, and it suggested cutoff values of 372.5 U/L. A prediction model based on the ROC analysis had 100 % sensitivity and 86.7 % specificity to predict liver abscess formation in patients with two of the three independent risk factors.

Conclusions: TAE, high-grade hepatic injury, and a high GPT level are independent risk factors for liver abscess formation.

原文英語
頁(從 - 到)547-552
頁數6
期刊European Journal of Trauma and Emergency Surgery
40
發行號5
DOIs
出版狀態已發佈 - 十月 16 2014
對外發佈Yes

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Orthopedics and Sports Medicine
  • Critical Care and Intensive Care Medicine

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    Hsu, C. P., Wang, S. Y., Hsu, Y. P., Chen, H. W., Lin, B. C., Kang, S. C., Yuan, K. C., Liu, E. H., Kuo, I. M., Liao, C. H., Ouyang, C. H., & Yang, S. J. (2014). Risk factors for liver abscess formation in patients with blunt hepatic injury after non-operative management. European Journal of Trauma and Emergency Surgery, 40(5), 547-552. https://doi.org/10.1007/s00068-013-0346-7