Risk factors and their interaction on chronic kidney disease

A multi-centre case control study in Taiwan

Sui Lung Su, Chin Lin, SenYeong Kao, Chia Chao Wu, Kuo Cheng Lu, Ching Huang Lai, Hsin Yi Yang, Yu Lung Chiu, Jin Shuen Chen, Fung Chang Sung, Ying Chin Ko, Chien Te Lee, Yu Yang, Chih Wei Yang, Shang Jyh Hwang, Ming Cheng Wang, Yung Ho Hsu, Mei Yi Wu, Yu Mei Hsueh, Hung Yi Chiou & 1 others Yuh Feng Lin

研究成果: 雜誌貢獻文章

13 引文 (Scopus)

摘要

Background: Chronic kidney disease (CKD) is highly prevalent in Taiwan. More than two-thirds of end-stage renal disease is associated with diabetes mellitus (DM) or hypertension (HTN). Therefore, the formulation of a special preventative policy of CKD in these patients is essential. This study surveyed 14 traditional risk factors and identified their effects on CKD in patients with HTN/DM and compared these with their effects in the general population. Methods: This study included 5328 cases and 5135 controls in the CKD/HTN/DM outpatient and health centres of 10 hospitals from 2008 to 2010. Fourteen common effect factors were surveyed (four demographic, five disease and five lifestyle), and their effects on CKD were tested. Significance tests were adjusted by the Bonferroni method. Results of the stratified analyses in the variables were presented with significant heterogeneity between patients with different comorbidities. Results: Male, ageing, low income, hyperuricemia and lack of exercise habits were risk factors for CKD, and their effects in people with different comorbidities were identical. Anaemia was a risk factor, and there was an additive effect between anaemia and HTN on CKD. Patients with anaemia had a higher risk when associated with HTN [odds ratio (OR)=6.75, 95 % confidence limit (95 % CI) 4.76-9.68] but had a smaller effect in people without HTN (OR 2.83, 95 % CI 2.16-3.67). The association between hyperlipidaemia-related factors and CKD was also moderated by HTN. It was a significant risk factor in people without HTN (OR=1.67, 95 % CI 1.38-2.01) but not in patients with HTN (OR =1.03, 95 % CI 0.89-1.19). Hepatitis B, hepatitis C, betel nut chewing, smoking, alcohol intake and groundwater use were not associated with CKD in multivariate analysis. Conclusions: We considered that patients with HTN and anaemia were a high CKD risk population. Physicians with anaemic patients in outpatient clinics need to recognise that patients who also have HTN might be latent CKD cases.
原文英語
文章編號83
期刊BMC Nephrology
16
發行號1
DOIs
出版狀態已發佈 - 六月 16 2015

指紋

Taiwan
Chronic Renal Insufficiency
Case-Control Studies
Hypertension
Anemia
Odds Ratio
Diabetes Mellitus
Comorbidity
Areca
Hyperuricemia
Mastication
Groundwater
Hepatitis C
Ambulatory Care Facilities
Hyperlipidemias
Hepatitis B
Population
Chronic Kidney Failure
Habits
Life Style

ASJC Scopus subject areas

  • Nephrology

引用此文

Risk factors and their interaction on chronic kidney disease : A multi-centre case control study in Taiwan. / Su, Sui Lung; Lin, Chin; Kao, SenYeong; Wu, Chia Chao; Lu, Kuo Cheng; Lai, Ching Huang; Yang, Hsin Yi; Chiu, Yu Lung; Chen, Jin Shuen; Sung, Fung Chang; Ko, Ying Chin; Lee, Chien Te; Yang, Yu; Yang, Chih Wei; Hwang, Shang Jyh; Wang, Ming Cheng; Hsu, Yung Ho; Wu, Mei Yi; Hsueh, Yu Mei; Chiou, Hung Yi; Lin, Yuh Feng.

於: BMC Nephrology, 卷 16, 編號 1, 83, 16.06.2015.

研究成果: 雜誌貢獻文章

Su, SL, Lin, C, Kao, S, Wu, CC, Lu, KC, Lai, CH, Yang, HY, Chiu, YL, Chen, JS, Sung, FC, Ko, YC, Lee, CT, Yang, Y, Yang, CW, Hwang, SJ, Wang, MC, Hsu, YH, Wu, MY, Hsueh, YM, Chiou, HY & Lin, YF 2015, 'Risk factors and their interaction on chronic kidney disease: A multi-centre case control study in Taiwan', BMC Nephrology, 卷 16, 編號 1, 83. https://doi.org/10.1186/s12882-015-0065-x
Su, Sui Lung ; Lin, Chin ; Kao, SenYeong ; Wu, Chia Chao ; Lu, Kuo Cheng ; Lai, Ching Huang ; Yang, Hsin Yi ; Chiu, Yu Lung ; Chen, Jin Shuen ; Sung, Fung Chang ; Ko, Ying Chin ; Lee, Chien Te ; Yang, Yu ; Yang, Chih Wei ; Hwang, Shang Jyh ; Wang, Ming Cheng ; Hsu, Yung Ho ; Wu, Mei Yi ; Hsueh, Yu Mei ; Chiou, Hung Yi ; Lin, Yuh Feng. / Risk factors and their interaction on chronic kidney disease : A multi-centre case control study in Taiwan. 於: BMC Nephrology. 2015 ; 卷 16, 編號 1.
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abstract = "Background: Chronic kidney disease (CKD) is highly prevalent in Taiwan. More than two-thirds of end-stage renal disease is associated with diabetes mellitus (DM) or hypertension (HTN). Therefore, the formulation of a special preventative policy of CKD in these patients is essential. This study surveyed 14 traditional risk factors and identified their effects on CKD in patients with HTN/DM and compared these with their effects in the general population. Methods: This study included 5328 cases and 5135 controls in the CKD/HTN/DM outpatient and health centres of 10 hospitals from 2008 to 2010. Fourteen common effect factors were surveyed (four demographic, five disease and five lifestyle), and their effects on CKD were tested. Significance tests were adjusted by the Bonferroni method. Results of the stratified analyses in the variables were presented with significant heterogeneity between patients with different comorbidities. Results: Male, ageing, low income, hyperuricemia and lack of exercise habits were risk factors for CKD, and their effects in people with different comorbidities were identical. Anaemia was a risk factor, and there was an additive effect between anaemia and HTN on CKD. Patients with anaemia had a higher risk when associated with HTN [odds ratio (OR)=6.75, 95 {\%} confidence limit (95 {\%} CI) 4.76-9.68] but had a smaller effect in people without HTN (OR 2.83, 95 {\%} CI 2.16-3.67). The association between hyperlipidaemia-related factors and CKD was also moderated by HTN. It was a significant risk factor in people without HTN (OR=1.67, 95 {\%} CI 1.38-2.01) but not in patients with HTN (OR =1.03, 95 {\%} CI 0.89-1.19). Hepatitis B, hepatitis C, betel nut chewing, smoking, alcohol intake and groundwater use were not associated with CKD in multivariate analysis. Conclusions: We considered that patients with HTN and anaemia were a high CKD risk population. Physicians with anaemic patients in outpatient clinics need to recognise that patients who also have HTN might be latent CKD cases.",
keywords = "Anaemia, Chronic kidney disease, Hyperlipidaemia, Hypertension, Interaction",
author = "Su, {Sui Lung} and Chin Lin and SenYeong Kao and Wu, {Chia Chao} and Lu, {Kuo Cheng} and Lai, {Ching Huang} and Yang, {Hsin Yi} and Chiu, {Yu Lung} and Chen, {Jin Shuen} and Sung, {Fung Chang} and Ko, {Ying Chin} and Lee, {Chien Te} and Yu Yang and Yang, {Chih Wei} and Hwang, {Shang Jyh} and Wang, {Ming Cheng} and Hsu, {Yung Ho} and Wu, {Mei Yi} and Hsueh, {Yu Mei} and Chiou, {Hung Yi} and Lin, {Yuh Feng}",
year = "2015",
month = "6",
day = "16",
doi = "10.1186/s12882-015-0065-x",
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TY - JOUR

T1 - Risk factors and their interaction on chronic kidney disease

T2 - A multi-centre case control study in Taiwan

AU - Su, Sui Lung

AU - Lin, Chin

AU - Kao, SenYeong

AU - Wu, Chia Chao

AU - Lu, Kuo Cheng

AU - Lai, Ching Huang

AU - Yang, Hsin Yi

AU - Chiu, Yu Lung

AU - Chen, Jin Shuen

AU - Sung, Fung Chang

AU - Ko, Ying Chin

AU - Lee, Chien Te

AU - Yang, Yu

AU - Yang, Chih Wei

AU - Hwang, Shang Jyh

AU - Wang, Ming Cheng

AU - Hsu, Yung Ho

AU - Wu, Mei Yi

AU - Hsueh, Yu Mei

AU - Chiou, Hung Yi

AU - Lin, Yuh Feng

PY - 2015/6/16

Y1 - 2015/6/16

N2 - Background: Chronic kidney disease (CKD) is highly prevalent in Taiwan. More than two-thirds of end-stage renal disease is associated with diabetes mellitus (DM) or hypertension (HTN). Therefore, the formulation of a special preventative policy of CKD in these patients is essential. This study surveyed 14 traditional risk factors and identified their effects on CKD in patients with HTN/DM and compared these with their effects in the general population. Methods: This study included 5328 cases and 5135 controls in the CKD/HTN/DM outpatient and health centres of 10 hospitals from 2008 to 2010. Fourteen common effect factors were surveyed (four demographic, five disease and five lifestyle), and their effects on CKD were tested. Significance tests were adjusted by the Bonferroni method. Results of the stratified analyses in the variables were presented with significant heterogeneity between patients with different comorbidities. Results: Male, ageing, low income, hyperuricemia and lack of exercise habits were risk factors for CKD, and their effects in people with different comorbidities were identical. Anaemia was a risk factor, and there was an additive effect between anaemia and HTN on CKD. Patients with anaemia had a higher risk when associated with HTN [odds ratio (OR)=6.75, 95 % confidence limit (95 % CI) 4.76-9.68] but had a smaller effect in people without HTN (OR 2.83, 95 % CI 2.16-3.67). The association between hyperlipidaemia-related factors and CKD was also moderated by HTN. It was a significant risk factor in people without HTN (OR=1.67, 95 % CI 1.38-2.01) but not in patients with HTN (OR =1.03, 95 % CI 0.89-1.19). Hepatitis B, hepatitis C, betel nut chewing, smoking, alcohol intake and groundwater use were not associated with CKD in multivariate analysis. Conclusions: We considered that patients with HTN and anaemia were a high CKD risk population. Physicians with anaemic patients in outpatient clinics need to recognise that patients who also have HTN might be latent CKD cases.

AB - Background: Chronic kidney disease (CKD) is highly prevalent in Taiwan. More than two-thirds of end-stage renal disease is associated with diabetes mellitus (DM) or hypertension (HTN). Therefore, the formulation of a special preventative policy of CKD in these patients is essential. This study surveyed 14 traditional risk factors and identified their effects on CKD in patients with HTN/DM and compared these with their effects in the general population. Methods: This study included 5328 cases and 5135 controls in the CKD/HTN/DM outpatient and health centres of 10 hospitals from 2008 to 2010. Fourteen common effect factors were surveyed (four demographic, five disease and five lifestyle), and their effects on CKD were tested. Significance tests were adjusted by the Bonferroni method. Results of the stratified analyses in the variables were presented with significant heterogeneity between patients with different comorbidities. Results: Male, ageing, low income, hyperuricemia and lack of exercise habits were risk factors for CKD, and their effects in people with different comorbidities were identical. Anaemia was a risk factor, and there was an additive effect between anaemia and HTN on CKD. Patients with anaemia had a higher risk when associated with HTN [odds ratio (OR)=6.75, 95 % confidence limit (95 % CI) 4.76-9.68] but had a smaller effect in people without HTN (OR 2.83, 95 % CI 2.16-3.67). The association between hyperlipidaemia-related factors and CKD was also moderated by HTN. It was a significant risk factor in people without HTN (OR=1.67, 95 % CI 1.38-2.01) but not in patients with HTN (OR =1.03, 95 % CI 0.89-1.19). Hepatitis B, hepatitis C, betel nut chewing, smoking, alcohol intake and groundwater use were not associated with CKD in multivariate analysis. Conclusions: We considered that patients with HTN and anaemia were a high CKD risk population. Physicians with anaemic patients in outpatient clinics need to recognise that patients who also have HTN might be latent CKD cases.

KW - Anaemia

KW - Chronic kidney disease

KW - Hyperlipidaemia

KW - Hypertension

KW - Interaction

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