Risk classification of cancer survival using ANN with gene expression data from multiple laboratories

Yen Chen Chen, Wan Chi Ke, Hung Wen Chiu

研究成果: 雜誌貢獻文章同行評審

63 引文 斯高帕斯(Scopus)

摘要

Numerous cancer studies have combined gene expression experiments and clinical survival data to predict the prognosis of patients of specific gene types. However, most results of these studies were data dependent and were not suitable for other data sets. This study performed cross-laboratory validations for the cancer patient data from 4 hospitals. We investigated the feasibility of survival risk predictions using high-throughput gene expression data and clinical data. We analyzed multiple data sets for prognostic applications in lung cancer diagnosis. After building tens of thousands of various ANN architectures using the training data, five survival-time correlated genes were identified from 4 microarray gene expression data sets by examining the correlation between gene signatures and patient survival time. The experimental results showed that gene expression data can be used for valid predictions of cancer patient survival classification with an overall accuracy of 83.0% based on survival time trusted data. The results show the prediction model yielded excellent predictions given that patients in the high-risk group obtained a lower median overall survival compared with low-risk patients (log-rank test P-value
原文英語
頁(從 - 到)1-7
頁數7
期刊Computers in Biology and Medicine
48
發行號1
DOIs
出版狀態已發佈 - 五月 1 2014

ASJC Scopus subject areas

  • 電腦科學應用
  • 健康資訊學
  • 醫藥 (全部)

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