Risk and adverse outcomes of fractures in patients with Parkinson’s disease

two nationwide studies

Y. F. Huang, Yih-Giun Cherng, S. P C Hsu, C. C. Yeh, Y. C. Chou, C. H. Wu, Ta-Liang Chen, Chien-Chang Liao

研究成果: 雜誌貢獻文章

12 引文 (Scopus)

摘要

Summary: The association between Parkinson’s disease and fracture was not completely understood. This nationwide study investigated increased risk of fracture in patients with Parkinson’s disease. In the nested cohort study, Parkinson’s disease was associated with pneumonia, septicemia, stroke, urinary tract infection, and mortality after fracture admission. Introduction: Falls are a common complication in people with Parkinson’s disease (PD). This study evaluated fracture risk and post-fracture outcomes in patients with PD. Methods: We identified 1,423 adults aged 40 years and older newly diagnosed with PD using the Taiwan National Health Insurance Research Database from 2000 to 2003. Comparison cohort consisted of 5,692 adults without PD randomly selected from the same dataset, frequency matched in age and sex. Followed-up events of fracture from January 1, 2000, until December 31, 2008, were ascertained from medical claims. Adjusted hazard ratios (HR) and 95 % confidence interval (CI) of fracture associated with PD were evaluated. Another nested cohort study of 397,766 hospitalized fracture patients analyzed for adjusted odds ratios (ORs) and 95 % CIs of adverse events after fracture among patients with and without PD between 2004 and 2010. Results: The incidences of fracture for people with and without PD were 39.5 and 23.9 per 1,000 person-years, respectively (p <0.0001). Compared with control, the adjusted HR of fracture was 2.25 (95 % CI 1.97–2.58) for PD patients. Previous PD was associated with risks of pneumonia (OR 1.44, 95 % CI 1.36–1.52), septicemia (OR 1.41, 95 % CI 1.33–1.49), stroke (OR 1.40, 95 % CI 1.32–1.50), urinary tract infection (OR 1.53, 95 % CI 1.46–1.61), and mortality (OR 1.25, 95 % CI 1.15–1.35) after fracture. Conclusions: PD was associated with higher risk of fracture. Patients with PD had more complications and mortality after fracture. Fracture prevention and attention to post-fracture adverse events are needed for this susceptible population.
原文英語
頁(從 - 到)1723-1732
頁數10
期刊Osteoporosis International
26
發行號6
DOIs
出版狀態已發佈 - 二月 12 2015

指紋

Parkinson Disease
Confidence Intervals
Odds Ratio
Urinary Tract Infections
Mortality
Sepsis
Pneumonia
Cohort Studies
Stroke
Safety Management
National Health Programs
Taiwan
Databases

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

引用此文

Risk and adverse outcomes of fractures in patients with Parkinson’s disease : two nationwide studies. / Huang, Y. F.; Cherng, Yih-Giun; Hsu, S. P C; Yeh, C. C.; Chou, Y. C.; Wu, C. H.; Chen, Ta-Liang; Liao, Chien-Chang.

於: Osteoporosis International, 卷 26, 編號 6, 12.02.2015, p. 1723-1732.

研究成果: 雜誌貢獻文章

@article{2ddef627a0134493b1734e3916889090,
title = "Risk and adverse outcomes of fractures in patients with Parkinson’s disease: two nationwide studies",
abstract = "Summary: The association between Parkinson’s disease and fracture was not completely understood. This nationwide study investigated increased risk of fracture in patients with Parkinson’s disease. In the nested cohort study, Parkinson’s disease was associated with pneumonia, septicemia, stroke, urinary tract infection, and mortality after fracture admission. Introduction: Falls are a common complication in people with Parkinson’s disease (PD). This study evaluated fracture risk and post-fracture outcomes in patients with PD. Methods: We identified 1,423 adults aged 40 years and older newly diagnosed with PD using the Taiwan National Health Insurance Research Database from 2000 to 2003. Comparison cohort consisted of 5,692 adults without PD randomly selected from the same dataset, frequency matched in age and sex. Followed-up events of fracture from January 1, 2000, until December 31, 2008, were ascertained from medical claims. Adjusted hazard ratios (HR) and 95 {\%} confidence interval (CI) of fracture associated with PD were evaluated. Another nested cohort study of 397,766 hospitalized fracture patients analyzed for adjusted odds ratios (ORs) and 95 {\%} CIs of adverse events after fracture among patients with and without PD between 2004 and 2010. Results: The incidences of fracture for people with and without PD were 39.5 and 23.9 per 1,000 person-years, respectively (p <0.0001). Compared with control, the adjusted HR of fracture was 2.25 (95 {\%} CI 1.97–2.58) for PD patients. Previous PD was associated with risks of pneumonia (OR 1.44, 95 {\%} CI 1.36–1.52), septicemia (OR 1.41, 95 {\%} CI 1.33–1.49), stroke (OR 1.40, 95 {\%} CI 1.32–1.50), urinary tract infection (OR 1.53, 95 {\%} CI 1.46–1.61), and mortality (OR 1.25, 95 {\%} CI 1.15–1.35) after fracture. Conclusions: PD was associated with higher risk of fracture. Patients with PD had more complications and mortality after fracture. Fracture prevention and attention to post-fracture adverse events are needed for this susceptible population.",
keywords = "Fracture, Mortality, Parkinson’s disease",
author = "Huang, {Y. F.} and Yih-Giun Cherng and Hsu, {S. P C} and Yeh, {C. C.} and Chou, {Y. C.} and Wu, {C. H.} and Ta-Liang Chen and Chien-Chang Liao",
year = "2015",
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doi = "10.1007/s00198-015-3052-y",
language = "English",
volume = "26",
pages = "1723--1732",
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TY - JOUR

T1 - Risk and adverse outcomes of fractures in patients with Parkinson’s disease

T2 - two nationwide studies

AU - Huang, Y. F.

AU - Cherng, Yih-Giun

AU - Hsu, S. P C

AU - Yeh, C. C.

AU - Chou, Y. C.

AU - Wu, C. H.

AU - Chen, Ta-Liang

AU - Liao, Chien-Chang

PY - 2015/2/12

Y1 - 2015/2/12

N2 - Summary: The association between Parkinson’s disease and fracture was not completely understood. This nationwide study investigated increased risk of fracture in patients with Parkinson’s disease. In the nested cohort study, Parkinson’s disease was associated with pneumonia, septicemia, stroke, urinary tract infection, and mortality after fracture admission. Introduction: Falls are a common complication in people with Parkinson’s disease (PD). This study evaluated fracture risk and post-fracture outcomes in patients with PD. Methods: We identified 1,423 adults aged 40 years and older newly diagnosed with PD using the Taiwan National Health Insurance Research Database from 2000 to 2003. Comparison cohort consisted of 5,692 adults without PD randomly selected from the same dataset, frequency matched in age and sex. Followed-up events of fracture from January 1, 2000, until December 31, 2008, were ascertained from medical claims. Adjusted hazard ratios (HR) and 95 % confidence interval (CI) of fracture associated with PD were evaluated. Another nested cohort study of 397,766 hospitalized fracture patients analyzed for adjusted odds ratios (ORs) and 95 % CIs of adverse events after fracture among patients with and without PD between 2004 and 2010. Results: The incidences of fracture for people with and without PD were 39.5 and 23.9 per 1,000 person-years, respectively (p <0.0001). Compared with control, the adjusted HR of fracture was 2.25 (95 % CI 1.97–2.58) for PD patients. Previous PD was associated with risks of pneumonia (OR 1.44, 95 % CI 1.36–1.52), septicemia (OR 1.41, 95 % CI 1.33–1.49), stroke (OR 1.40, 95 % CI 1.32–1.50), urinary tract infection (OR 1.53, 95 % CI 1.46–1.61), and mortality (OR 1.25, 95 % CI 1.15–1.35) after fracture. Conclusions: PD was associated with higher risk of fracture. Patients with PD had more complications and mortality after fracture. Fracture prevention and attention to post-fracture adverse events are needed for this susceptible population.

AB - Summary: The association between Parkinson’s disease and fracture was not completely understood. This nationwide study investigated increased risk of fracture in patients with Parkinson’s disease. In the nested cohort study, Parkinson’s disease was associated with pneumonia, septicemia, stroke, urinary tract infection, and mortality after fracture admission. Introduction: Falls are a common complication in people with Parkinson’s disease (PD). This study evaluated fracture risk and post-fracture outcomes in patients with PD. Methods: We identified 1,423 adults aged 40 years and older newly diagnosed with PD using the Taiwan National Health Insurance Research Database from 2000 to 2003. Comparison cohort consisted of 5,692 adults without PD randomly selected from the same dataset, frequency matched in age and sex. Followed-up events of fracture from January 1, 2000, until December 31, 2008, were ascertained from medical claims. Adjusted hazard ratios (HR) and 95 % confidence interval (CI) of fracture associated with PD were evaluated. Another nested cohort study of 397,766 hospitalized fracture patients analyzed for adjusted odds ratios (ORs) and 95 % CIs of adverse events after fracture among patients with and without PD between 2004 and 2010. Results: The incidences of fracture for people with and without PD were 39.5 and 23.9 per 1,000 person-years, respectively (p <0.0001). Compared with control, the adjusted HR of fracture was 2.25 (95 % CI 1.97–2.58) for PD patients. Previous PD was associated with risks of pneumonia (OR 1.44, 95 % CI 1.36–1.52), septicemia (OR 1.41, 95 % CI 1.33–1.49), stroke (OR 1.40, 95 % CI 1.32–1.50), urinary tract infection (OR 1.53, 95 % CI 1.46–1.61), and mortality (OR 1.25, 95 % CI 1.15–1.35) after fracture. Conclusions: PD was associated with higher risk of fracture. Patients with PD had more complications and mortality after fracture. Fracture prevention and attention to post-fracture adverse events are needed for this susceptible population.

KW - Fracture

KW - Mortality

KW - Parkinson’s disease

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JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

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ER -