@article{dfa5f093e63741c2a0b3d863840e295d,
title = "Ring size changes in the development of class I HDAC inhibitors",
abstract = "Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.",
keywords = "colon cancer, HDAC, ring transformation, Thienylbenzamides",
author = "Cho, {Er Chieh} and Liu, {Chi Yuan} and Tang, {Di Wei} and Lee, {Hsueh Yun}",
note = "Funding Information: This research was supported by the Ministry of Science and Technology, Taiwan [grant no. MOST108-2320-B-038-042-MY3 and MOST 109-2320-B-038-038], Taiwan, and WanFang Hospital, Chi-Mei Medical Center, and Hualien Tzu-Chi Hospital Joint Cancer Center Grant-Focus on Colon Cancer Research [MOHW109-TDU-B-212-134020, supported by Health and welfare surcharge of tobacco products], Taiwan. Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",
year = "2021",
doi = "10.1080/14756366.2021.1941920",
language = "English",
volume = "36",
pages = "1387--1401",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
issn = "1475-6366",
publisher = "Informa Healthcare",
number = "1",
}
