Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25

Chun Kuang Shih, Chiao-Ming Chen, C. Y Oliver Chen, Jen-Fang Liu, Hui Wen Lin, Hung Tsung Chou, Sing Chung Li

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Riboflavin (vitamin B2) is a water-soluble vitamin essential for normal cellular functions, growth and development. This study aimed to investigate the effects of vitamin B2 on the survival rate, and expressions of tissue heat shock protein 25 (HSP25) and heat shock factor 1 (HSF1) in mice undergoing lipopolysaccharide (LPS) induced shock. Mice were assigned to four groups, saline vehicle, LPS, LPS plus low dose of vitamin B2 (LB2) and LPS plus high dose of vitamin B2 (HB2). Vitamin B2 (1 and 10. mg/kg BW) was administered intraperitoneally at 2 and 0. h before the i.p. administration of LPS. At the end of the experiment, the survival rate monitored was 10, 20, 60, and 100% for LPS, LB2, HB2, and saline mice, respectively. HSP25 expressions in the heart and lung were significantly enhanced in a time-dependent manner in the HB2 mice as compared to the saline mice (p<0.05), but not altered in the LB2 mice. In the HB2 mice, plasma riboflavin concentrations reached 300. nM at 6. h post LPS and returned to the 0. h level at 72. h. The results showed that high dose of riboflavin could decrease LPS-induced mortality through an increased expression of HSP25.

原文英語
頁(從 - 到)1913-1918
頁數6
期刊Food and Chemical Toxicology
48
發行號7
DOIs
出版狀態已發佈 - 七月 2010

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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