TY - JOUR
T1 - Reversible posterior leukoencephalopathy syndrome caused by blood transfusion
T2 - A case report
AU - Huang, Yung Chuan
AU - Tsai, Pei Lin
AU - Yeh, Jiann Horng
AU - Chen, Wei Hung
PY - 2008/12
Y1 - 2008/12
N2 - This is a case report of a 32-year-old woman with chronic severe anemia who developed headaches and seizures 5 days after receiving a blood transfusion of eight units (1600 ml) of packed red blood cells. Magnetic resonance imaging indicated vasogenic edematous lesions bilaterally over the occipital lobes that were consistent with reversible posterior leukoencephalopathy syndrome (RPLS). Her blood pressure was normal, and no other contributing factors for RPLS were found. It is likely that the initiator was the large volume of transfused blood, which disrupted cerebral autoregulation and damaged the vasculoendothelial system. Similar cases of RPLS following transfusion have been reported, and all reports involved middle-aged females with chronic severe anemia who received large volumes of transfused blood within a short period of time. Although blood transfusion is a common procedure with rare neurological complications, great caution should be taken with chronic severely anemic patients because a rapid elevation in hemoglobin may precipitate RPLS.
AB - This is a case report of a 32-year-old woman with chronic severe anemia who developed headaches and seizures 5 days after receiving a blood transfusion of eight units (1600 ml) of packed red blood cells. Magnetic resonance imaging indicated vasogenic edematous lesions bilaterally over the occipital lobes that were consistent with reversible posterior leukoencephalopathy syndrome (RPLS). Her blood pressure was normal, and no other contributing factors for RPLS were found. It is likely that the initiator was the large volume of transfused blood, which disrupted cerebral autoregulation and damaged the vasculoendothelial system. Similar cases of RPLS following transfusion have been reported, and all reports involved middle-aged females with chronic severe anemia who received large volumes of transfused blood within a short period of time. Although blood transfusion is a common procedure with rare neurological complications, great caution should be taken with chronic severely anemic patients because a rapid elevation in hemoglobin may precipitate RPLS.
KW - Cerebral autoregulation
KW - Hyperperfusion syndrome
KW - Posterior leukoencephalopathy
KW - Transfusion complication
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M3 - Article
C2 - 19280871
AN - SCOPUS:58149277032
VL - 17
SP - 258
EP - 262
JO - Acta Neurologica Taiwanica
JF - Acta Neurologica Taiwanica
SN - 1019-6099
IS - 4
ER -