Retrovirus insertion into herpesvirus in vitro and in vivo

R. Isfort, D. Jones, R. Kost, R. Witter, H. J. Kung

研究成果: 雜誌貢獻文章同行評審

128 引文 斯高帕斯(Scopus)

摘要

Retroviruses and herpesviruses are naturally occurring pathogens of humans and animals. Coinfection of the same host with both these viruses is common. We report here that a retrovirus can integrate directly into a herpesvirus genome. Specifically, we demonstrate insertion of a nonacute retrovirus, reticuloendotheliosis virus (REV), into a herpesvirus, Marek disease virus (MDV). Both viruses are capable of inducing T lymphomas in chickens and often coexist in the same animal. REV DNA integration into MDV occurred in a recently attenuated strain of MDV and in a short-term coinfection experiment in vitro. We also provide suggestive evidence that REV has inserted into pathogenic strains of MDV in the past. Sequences homologous to the REV long terminal repeat are found in oncogenic MDV but not in nononcogenic strains. These results raise the possibility that retroviral information may be transmitted by herpesvirus and that herpesvirus expression can be modulated by retroviral elements. In addition, retrovirus may provide a useful tool to characterize herpesviral function by insertional mutagenesis.
原文英語
頁(從 - 到)991-995
頁數5
期刊Proceedings of the National Academy of Sciences of the United States of America
89
發行號3
DOIs
出版狀態已發佈 - 一月 1 1992
對外發佈

ASJC Scopus subject areas

  • 多學科

指紋

深入研究「Retrovirus insertion into herpesvirus in vitro and in vivo」主題。共同形成了獨特的指紋。

引用此