Retrospective Seroepidemiology study of dengue virus infection in Taiwan

Ying Hsuan Lee, Yu Chia Hsieh, Chih Jung Chen, Tzou Yien Lin, Yhu Chering Huang

研究成果: 雜誌貢獻文章同行評審

摘要

Background: Dengue virus infection has been an important and serious public health concern in Taiwan, where local outbreaks of dengue fever occurred almost every year. To our knowledge, no nationwide investigation has been carried out to determine the actual extent of infection in the general population. Methods: A total of 1308 random serum samples were collected from the general population in Taiwan in 2010. The antibody-captured enzyme-linked immunosorbent assays were used to detect DENV-specific IgM and IgG. Demographics data were used for risk analysis. Results: The weighted overall seroprevalence was 1.96% for anti-DENV IgM, and 3.4% for anti-DENV IgG, respectively. A significant rise of DENV IgG seropositive rate had been noted since late adulthood stage, from 1.1% at the age group of 50–59 years to 7.6% at the age group of 60–69 years. For people aged over 70 years, the seropositive rate reached 19%. Age, nationality, and regions of residency were associated with the IgG seropositivity. There was no statistically significant difference in seroprevalence of anti-Dengue IgM, indicating recent infection, among univariate predictors we proposed, including gender, age, residency, nationality, and household size. Conclusions: Our results indicated that the majority of population in Taiwan born after 1940 is naive to dengue virus and the prevalence of IgG antibody against dengue virus rises with age. Nationality, and regions of residency are associated with the exposure of population to infection by dengue viruses. Further studies are needed to realize the current situation of seroprevalence of dengue fever in Taiwan.

原文英語
文章編號96
期刊BMC Infectious Diseases
21
發行號1
DOIs
出版狀態已發佈 - 12月 2021
對外發佈

ASJC Scopus subject areas

  • 傳染性疾病

指紋

深入研究「Retrospective Seroepidemiology study of dengue virus infection in Taiwan」主題。共同形成了獨特的指紋。

引用此