Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies

Bruce E. Johnson, Jacqueline Whang-peng, Susan L. Naylor, Berton Zbar, Hiltrud Brauch, Elaine Lee, Alfreda Simmons, Edward Russell, Myong H. Nam, Adi F. Gazdar

研究成果: 雜誌貢獻文章

41 引文 (Scopus)

摘要

In small cell lung carcinoma, one of the short arms of chromosome 3 is typically lost. To investigate chromosome 3 in extrapulmonary small cell carcinoma, we used DNA probes that detect restriction-fragment-length polymorphisms at loci on 3p. These probes were used to study DNA extracted from tumors and normal tissues and/or tumor cell lines from five patients with extrapulmonary small cell cancer. Tumor DNA from four of the five patients with extrapulmonary small cell cancer retained heterozygosity at loci on 3p. Cytogenetic studies of the tumor cell lines established from these four patients showed retention of both short arms of chromosome 3. We conclude that the loss of genetic material from 3p observed in small cell lung cancer is not typical in extrapulmonary small cell cancer. [J Natl Cancer Inst 81:1223-1228, 1989].
原文英語
頁(從 - 到)1223-1228
頁數6
期刊Journal of the National Cancer Institute
81
發行號16
DOIs
出版狀態已發佈 - 八月 16 1989
對外發佈Yes

指紋

Chromosomes, Human, Pair 3
Cytogenetics
Neoplasms
Small Cell Lung Carcinoma
Tumor Cell Line
Small Cell Carcinoma
DNA
DNA Probes
Restriction Fragment Length Polymorphisms
Genes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

引用此文

Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies. / Johnson, Bruce E.; Whang-peng, Jacqueline; Naylor, Susan L.; Zbar, Berton; Brauch, Hiltrud; Lee, Elaine; Simmons, Alfreda; Russell, Edward; Nam, Myong H.; Gazdar, Adi F.

於: Journal of the National Cancer Institute, 卷 81, 編號 16, 16.08.1989, p. 1223-1228.

研究成果: 雜誌貢獻文章

Johnson, BE, Whang-peng, J, Naylor, SL, Zbar, B, Brauch, H, Lee, E, Simmons, A, Russell, E, Nam, MH & Gazdar, AF 1989, 'Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies', Journal of the National Cancer Institute, 卷 81, 編號 16, 頁 1223-1228. https://doi.org/10.1093/jnci/81.16.1223
Johnson, Bruce E. ; Whang-peng, Jacqueline ; Naylor, Susan L. ; Zbar, Berton ; Brauch, Hiltrud ; Lee, Elaine ; Simmons, Alfreda ; Russell, Edward ; Nam, Myong H. ; Gazdar, Adi F. / Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies. 於: Journal of the National Cancer Institute. 1989 ; 卷 81, 編號 16. 頁 1223-1228.
@article{0d255e5755cc43649ed1bc3cddf93258,
title = "Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies",
abstract = "In small cell lung carcinoma, one of the short arms of chromosome 3 is typically lost. To investigate chromosome 3 in extrapulmonary small cell carcinoma, we used DNA probes that detect restriction-fragment-length polymorphisms at loci on 3p. These probes were used to study DNA extracted from tumors and normal tissues and/or tumor cell lines from five patients with extrapulmonary small cell cancer. Tumor DNA from four of the five patients with extrapulmonary small cell cancer retained heterozygosity at loci on 3p. Cytogenetic studies of the tumor cell lines established from these four patients showed retention of both short arms of chromosome 3. We conclude that the loss of genetic material from 3p observed in small cell lung cancer is not typical in extrapulmonary small cell cancer. [J Natl Cancer Inst 81:1223-1228, 1989].",
author = "Johnson, {Bruce E.} and Jacqueline Whang-peng and Naylor, {Susan L.} and Berton Zbar and Hiltrud Brauch and Elaine Lee and Alfreda Simmons and Edward Russell and Nam, {Myong H.} and Gazdar, {Adi F.}",
year = "1989",
month = "8",
day = "16",
doi = "10.1093/jnci/81.16.1223",
language = "English",
volume = "81",
pages = "1223--1228",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "16",

}

TY - JOUR

T1 - Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies

AU - Johnson, Bruce E.

AU - Whang-peng, Jacqueline

AU - Naylor, Susan L.

AU - Zbar, Berton

AU - Brauch, Hiltrud

AU - Lee, Elaine

AU - Simmons, Alfreda

AU - Russell, Edward

AU - Nam, Myong H.

AU - Gazdar, Adi F.

PY - 1989/8/16

Y1 - 1989/8/16

N2 - In small cell lung carcinoma, one of the short arms of chromosome 3 is typically lost. To investigate chromosome 3 in extrapulmonary small cell carcinoma, we used DNA probes that detect restriction-fragment-length polymorphisms at loci on 3p. These probes were used to study DNA extracted from tumors and normal tissues and/or tumor cell lines from five patients with extrapulmonary small cell cancer. Tumor DNA from four of the five patients with extrapulmonary small cell cancer retained heterozygosity at loci on 3p. Cytogenetic studies of the tumor cell lines established from these four patients showed retention of both short arms of chromosome 3. We conclude that the loss of genetic material from 3p observed in small cell lung cancer is not typical in extrapulmonary small cell cancer. [J Natl Cancer Inst 81:1223-1228, 1989].

AB - In small cell lung carcinoma, one of the short arms of chromosome 3 is typically lost. To investigate chromosome 3 in extrapulmonary small cell carcinoma, we used DNA probes that detect restriction-fragment-length polymorphisms at loci on 3p. These probes were used to study DNA extracted from tumors and normal tissues and/or tumor cell lines from five patients with extrapulmonary small cell cancer. Tumor DNA from four of the five patients with extrapulmonary small cell cancer retained heterozygosity at loci on 3p. Cytogenetic studies of the tumor cell lines established from these four patients showed retention of both short arms of chromosome 3. We conclude that the loss of genetic material from 3p observed in small cell lung cancer is not typical in extrapulmonary small cell cancer. [J Natl Cancer Inst 81:1223-1228, 1989].

UR - http://www.scopus.com/inward/record.url?scp=0024386775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024386775&partnerID=8YFLogxK

U2 - 10.1093/jnci/81.16.1223

DO - 10.1093/jnci/81.16.1223

M3 - Article

C2 - 2569043

AN - SCOPUS:0024386775

VL - 81

SP - 1223

EP - 1228

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 16

ER -