Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease

Yuh Feng Lin, Yu Hsuan Lee, Yung Ho Hsu, Yi Jie Chen, Yuan Feng Lin, Fong Yu Cheng, Hui Wen Chiu

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Aim: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Materials & methods: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. Results: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD. Conclusion: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.
原文英語
頁(從 - 到)2741-2756
頁數16
期刊Nanomedicine
12
發行號22
DOIs
出版狀態已發佈 - 十一月 1 2017

指紋

Resveratrol
Drug Delivery Systems
Chronic Renal Insufficiency
Nanoparticles
Kidney
Molecules
Wounds and Injuries
Inflammasomes
Autophagy
Pharmacokinetics
resveratrol
Interleukin-1
Antibodies
Toxicity
Blood Cells
Creatinine
Blood
Safety

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

引用此文

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title = "Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease",
abstract = "Aim: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Materials & methods: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. Results: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD. Conclusion: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.",
keywords = "autophagy, chronic kidney disease, inflammasome, kidney injury molecule-1, resveratrol",
author = "Lin, {Yuh Feng} and Lee, {Yu Hsuan} and Hsu, {Yung Ho} and Chen, {Yi Jie} and Lin, {Yuan Feng} and Cheng, {Fong Yu} and Chiu, {Hui Wen}",
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T1 - Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease

AU - Lin, Yuh Feng

AU - Lee, Yu Hsuan

AU - Hsu, Yung Ho

AU - Chen, Yi Jie

AU - Lin, Yuan Feng

AU - Cheng, Fong Yu

AU - Chiu, Hui Wen

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Aim: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Materials & methods: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. Results: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD. Conclusion: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.

AB - Aim: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Materials & methods: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. Results: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD. Conclusion: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.

KW - autophagy

KW - chronic kidney disease

KW - inflammasome

KW - kidney injury molecule-1

KW - resveratrol

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