Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-κB pathway and subsequently downregulating expression of matrix metalloproteinases

Po Len Liu, Jong Rung Tsai, Albert Linton Charles, Jhi Jhu Hwang, Shah Hwa Chou, Yueh Hsin Ping, Feng Yen Lin, Yuh Lien Chen, Chun Ying Hung, Wen Chi Chen, Yung Hsiang Chen, Inn Wen Chong

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94 引文 斯高帕斯(Scopus)

摘要

Resveratrol exhibits potential anti-carcinogenic activities. Heme oxygenase-1 (HO-1) is involved in angiogenesis and tumor metastasis. Matrix metalloproteinases (MMPs) are key enzymes in the degradation of extracellular matrix, and their expression may be dysregulated in lung cancer metastasis. In this study, we investigated the anti-invasive mechanism of resveratrol in lung cancer cells. HO-1 was shown to be elevated (~4.7-fold) in lung cancer tumor samples as compared with matched normal tissues. After treatment of lung adenocarcinoma cell line A549 cells with resveratrol (50μM) for 24h, the migratory and invasive abilities (38 and 30% inhibition, respectively) of A549 cells were significantly reduced. Resveratrol significantly inhibited HO-1-mediated MMP-9 (35% inhibition) and MMP-2 (28% inhibition) expression in lung cancer cells. Nuclear factor (NF)-κB inhibitor induced a marked reduction in MMP-9 and MMP-2 expression, suggesting NF-κB pathway could play an important role. Furthermore, HO-1 inhibition and silencing significantly suppressed MMPs and invasion of lung cancer cells. Our results suggest that resveratrol inhibited HO-1 and subsequently MMP-9 and MMP-2 expression in lung cancer cells. The inhibitory effects of resveratrol on MMP expression and invasion of lung cancer cells are, in part, associated with the HO-1-mediated NF-κB pathway.

原文英語
頁(從 - 到)S196-S204
期刊Molecular Nutrition and Food Research
54
發行號SUPPL. 2
DOIs
出版狀態已發佈 - 七月 2010

ASJC Scopus subject areas

  • 生物技術
  • 食品科學

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