Resveratrol enhances therapeutic effect on pancreatic regeneration in diabetes mellitus rats receiving autologous transplantation of adipose-derived stem cells

Tung Sheng Chen, Pei Fang Lai, Pei Fang Lai, Chia Hua Kuo, Cecilia Day, Ray Jade Chen, Tsung Jung Ho, Yu Lan Yeh, Yu Lan Yeh, B. Mahalakshmi, Vijaya Padmaviswanadha, Wei Wen Kuo, Chih Yang Huang, Chih Yang Huang, Chih Yang Huang, Chih Yang Huang

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Pancreatic damage is the major causative agent in type 1 diabetes mellitus (DM). Several strategies have been suggested to regenerate pancreatic functions, such as stem cell transplantation and administration of active components isolating from natural herbals. This study aims to investigate if the synergistically protective effect on damaged pancreatic tissues can be observed in STZ-induced DM rats with autologous transplantation of adipose-derived stem cells (ADSC) coupling with oral administration of resveratrol. Pathological conditions can be recognized in DM rats with pancreatic damage, including reduction of islet size, suppression of survival markers, downregulation of AMPK/Sirt1 axis, and activation of apoptotic signaling. Autologous transplantation of ADSC slightly improves pancreatic functions, whereas autologous transplantation of ADSC coupling with oral administration of resveratrol significantly improves pancreatic functions in DM rats. We suggest that oral administration of resveratrol may enhance the therapeutic effect on DM patients receiving autologous transplantation of ADSC.

原文英語
頁(從 - 到)122-127
頁數6
期刊Chinese Journal of Physiology
63
發行號3
DOIs
出版狀態已發佈 - 5月 1 2020

ASJC Scopus subject areas

  • 生理學
  • 生理學(醫學)

指紋

深入研究「Resveratrol enhances therapeutic effect on pancreatic regeneration in diabetes mellitus rats receiving autologous transplantation of adipose-derived stem cells」主題。共同形成了獨特的指紋。

引用此