Resveratrol ameliorates renal damage, Increases expression of heme oxygenase-1, And has anti-Complement, Anti-Oxidative, And Anti-Apoptotic effects in a murine model of membranous nephropathy

Chia Chao Wu, Yen Sung Huang, Jin Shuen Chen, Ching Feng Huang, Sui Lung Su, Kuo Cheng Lu, Yuh Feng Lin, Pauling Chu, Shih Hua Lin, Huey Kang Sytwu

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32 引文 斯高帕斯(Scopus)

摘要

Background Idiopathic membranous nephropathy (MN) is an autoimmune-mediated glomerulonephritis and a common cause of nephrotic syndrome in adults. There are limited available treatments for MN. We assessed the efficacy of resveratrol (RSV) therapy for treatment of MN in a murine model of this disease. Methods Murine MN was experimentally induced by daily subcutaneous administration of cationic bovine serum albumin, with phosphate-buffered saline used in control mice. MN mice were untreated or given RSV. Disease severity and pathogenesis was assessed by determination of metabolic and histopathology profiles, lymphocyte subsets, immunoglobulin production, oxidative stress, apoptosis, and production of heme oxygenase-1 (HO1). Results MN mice given RSV had significantly reduced proteinuria and a marked amelioration of glomerular lesions. RSV also significantly attenuated immunofluorescent staining of C3, although there were no changes of serum immunoglobulin levels or immunocomplex deposition in the kidneys. RSV treatment of MN mice also reduced the production of reactive oxygen species (ROS), reduced cell apoptosis, and upregulated heme oxygenase 1 (HO1). Inhibition of HO1 with tin protoporphyrin IX partially reversed the renoprotective effects of RSV. The HO1 induced by RSV maybe via Nrf2 signaling. Conclusion Our results show that RSV increased the expression of HO1 and ameliorated the effects of membranous nephropathy in a mouse model due to its anti-complement, anti-oxidative, and anti-apoptotic effects. RSV appears to have potential as a treatment for MN.

原文英語
文章編號0125726
期刊PLoS ONE
10
發行號5
DOIs
出版狀態已發佈 - 5月 1 2015

ASJC Scopus subject areas

  • 多學科

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