Results of three-dimensional conformal radiotherapy and thalidomide for advanced hepatocellular carcinoma

Wei Chung Hsu, Sue Ching Chan, Lai Lei Ting, Na Na Chung, Po Ming Wang, K. S Kung Shih Ying, Jeng Shiann Shin, Che Jen Chao, Gau De Lin

研究成果: 雜誌貢獻文章同行評審

20 引文 斯高帕斯(Scopus)

摘要

Purpose: To evaluate the effectiveness of three-dimensional conformal radiotherapy and thalidomide in the treatment of advanced hepatocellular carcinoma. Methods: Between 1999 and 2003, 121 patients (mean age, 54.4 ± 12.4 years; range, 20-81 years) with advanced hepatocellular carcinoma received three-dimensional conformal radiotherapy and thalidomide. Radiation was delivered in 1.5 Gy fractions twice daily for 5 days a week, for a total dose of 45-75 Gy. Mean treatment volume was 429.52 ± 408.50 cm3 (range, 26.89-2284.82 cm3). Thalidomide was given concomitantly: 200 mg/day in 109 patients, 300 mg/ day in 8 patients and 400 mg/day in 4 patients. Treatment responses0, survival rates and factors affecting survival were analyzed. Results: Treatment responses were observed in 61% of the patients. Liver cirrhosis (P = 0.001) and tumor size (P = 0.001) significantly affected the tumor responses. Overall survival at 6, 12 and 24 months was 84.8, 60.0 and 44.6%, respectively. On univariate analysis, liver cirrhosis (P = 0.003), Karnofsky performance status (P = 0.007), tumor size (P < 0.001), portal vein tumor thrombosis (P < 0.001) and alpha-fetoprotein level (P = 0.003) were shown to significantly affect survival. On multivariate analysis, only thrombosis (P = 0.039) and alpha-fetoprotein level (P = 0.006) were shown to be factors affecting survival. Conclusions: Three-dimensional conformal radiotherapy with thalidomide seems to be effective in the treatment of advanced hepatocellular carcinoma.

原文英語
頁(從 - 到)93-99
頁數7
期刊Japanese Journal of Clinical Oncology
36
發行號2
DOIs
出版狀態已發佈 - 2月 1 2006
對外發佈

ASJC Scopus subject areas

  • 腫瘤科

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