TY - JOUR
T1 - Resting-state functional magnetic resonance imaging
T2 - Review of neurosurgical applications
AU - Lang, Stefan
AU - Duncan, Niall
AU - Northoff, Georg
PY - 2014
Y1 - 2014
N2 - Recent research in brain imaging has highlighted the role of different neural networks in the resting state (ie, no task) in which the brain displays spontaneous low-frequency neuronal oscillations. These can be indirectly measured with resting-state functional magnetic resonance imaging, and functional connectivity can be inferred as the spatiotemporal correlations of this signal. This technique has proliferated in recent years and has allowed the noninvasive investigation of large-scale, distributed functional networks. In this review, we give a brief overview of resting-state networks and examine the use of resting-state functional magnetic resonance imaging in neurosurgical contexts, specifically with respect to neurooncology, epilepsy surgery, and deep brain stimulation. We discuss the advantages and disadvantages compared with task-based functional magnetic resonance imaging, the limitations of resting-state functional magnetic resonance imaging, and the emerging directions of this relatively new technology. ABBREVIATIONS:: BOLD, blood oxygen level-dependentDBS, deep brain stimulationICA, independent component analysisMTLE, medial temporal lobe epilepsyROI, region of interestrs-fMRI, resting-state functional magnetic resonance imagingRSN, resting-state network
AB - Recent research in brain imaging has highlighted the role of different neural networks in the resting state (ie, no task) in which the brain displays spontaneous low-frequency neuronal oscillations. These can be indirectly measured with resting-state functional magnetic resonance imaging, and functional connectivity can be inferred as the spatiotemporal correlations of this signal. This technique has proliferated in recent years and has allowed the noninvasive investigation of large-scale, distributed functional networks. In this review, we give a brief overview of resting-state networks and examine the use of resting-state functional magnetic resonance imaging in neurosurgical contexts, specifically with respect to neurooncology, epilepsy surgery, and deep brain stimulation. We discuss the advantages and disadvantages compared with task-based functional magnetic resonance imaging, the limitations of resting-state functional magnetic resonance imaging, and the emerging directions of this relatively new technology. ABBREVIATIONS:: BOLD, blood oxygen level-dependentDBS, deep brain stimulationICA, independent component analysisMTLE, medial temporal lobe epilepsyROI, region of interestrs-fMRI, resting-state functional magnetic resonance imagingRSN, resting-state network
KW - Fmri
KW - Neurosurgery
UR - http://www.scopus.com/inward/record.url?scp=84899642768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899642768&partnerID=8YFLogxK
U2 - 10.1227/NEU.0000000000000307
DO - 10.1227/NEU.0000000000000307
M3 - Article
C2 - 24492661
AN - SCOPUS:84899642768
VL - 74
SP - 453
EP - 464
JO - Neurosurgery
JF - Neurosurgery
SN - 0148-396X
IS - 5
ER -