Resistin mRNA levels are downregulated by estrogen in vivo and in vitro

Seng Wong Huang, Kok Min Seow, Low Tone Ho, Yueh Chien, Dong Yue Chung, Chih Ling Chang, Ying Hsiu Lai, Jiann Loung Hwang, Chi Chang Juan

研究成果: 雜誌貢獻文章

42 引文 (Scopus)

摘要

Resistin, a hormone secreted by adipocytes, is suggested to be an important link between obesity and diabetes. The aim of this study was to evaluate the regulatory effect of estrogen on adipocyte resistin gene expression in ovariectomized (OVX) rats and in isolated rat adipocytes in vitro. Subcutaneous injection of estradiol benzoate reduced resistin mRNA levels in adipocytes isolated from the inguinal, parametrial, perirenal, retroperitoneal, or periovarian fat deposits of OVX rats, while an in vitro study showed that estradiol treatment decreased resistin mRNA levels in cultured rat periovarian fat adipocytes. Results of Western blotting analysis also showed that estrogen decreased adipose resistin contents in vivo and in vitro. These data suggest that estrogen is a pivotal negative regulator of resistin gene expression.
原文英語
頁(從 - 到)449-454
頁數6
期刊FEBS Letters
579
發行號2
DOIs
出版狀態已發佈 - 一月 17 2005

指紋

Resistin
Estrogens
Adipocytes
Down-Regulation
Messenger RNA
Rats
Gene expression
Fats
Gene Expression
Groin
Subcutaneous Injections
Regulator Genes
Medical problems
In Vitro Techniques
Estradiol
Deposits
Obesity
Western Blotting
Hormones

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

引用此文

Huang, S. W., Seow, K. M., Ho, L. T., Chien, Y., Chung, D. Y., Chang, C. L., ... Juan, C. C. (2005). Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. FEBS Letters, 579(2), 449-454. https://doi.org/10.1016/j.febslet.2004.12.010

Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. / Huang, Seng Wong; Seow, Kok Min; Ho, Low Tone; Chien, Yueh; Chung, Dong Yue; Chang, Chih Ling; Lai, Ying Hsiu; Hwang, Jiann Loung; Juan, Chi Chang.

於: FEBS Letters, 卷 579, 編號 2, 17.01.2005, p. 449-454.

研究成果: 雜誌貢獻文章

Huang, SW, Seow, KM, Ho, LT, Chien, Y, Chung, DY, Chang, CL, Lai, YH, Hwang, JL & Juan, CC 2005, 'Resistin mRNA levels are downregulated by estrogen in vivo and in vitro', FEBS Letters, 卷 579, 編號 2, 頁 449-454. https://doi.org/10.1016/j.febslet.2004.12.010
Huang SW, Seow KM, Ho LT, Chien Y, Chung DY, Chang CL 等. Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. FEBS Letters. 2005 1月 17;579(2):449-454. https://doi.org/10.1016/j.febslet.2004.12.010
Huang, Seng Wong ; Seow, Kok Min ; Ho, Low Tone ; Chien, Yueh ; Chung, Dong Yue ; Chang, Chih Ling ; Lai, Ying Hsiu ; Hwang, Jiann Loung ; Juan, Chi Chang. / Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. 於: FEBS Letters. 2005 ; 卷 579, 編號 2. 頁 449-454.
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