摘要
| 原文 | 英語 |
|---|---|
| 期刊 | Nutrients |
| 卷 | 10 |
| 發行號 | 10 |
| DOIs | |
| 出版狀態 | 已發佈 - 十月 17 2018 |
指紋
Keywords
- antroquinonol
- hypertension
- inflammation
- nitric oxide
- Nrf-2
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
引用此文
Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension. / Chen, Jiun Rong; Ko, Jung; Yeh, Wan Ju; Huang, Wen Chih; Yang, Hsin Yi.
於: Nutrients, 卷 10, 編號 10, 17.10.2018.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension
AU - Chen, Jiun Rong
AU - Ko, Jung
AU - Yeh, Wan Ju
AU - Huang, Wen Chih
AU - Yang, Hsin Yi
PY - 2018/10/17
Y1 - 2018/10/17
N2 - Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day Nω-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction.
AB - Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day Nω-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction.
KW - antroquinonol
KW - hypertension
KW - inflammation
KW - nitric oxide
KW - Nrf-2
KW - antroquinonol
KW - hypertension
KW - inflammation
KW - nitric oxide
KW - Nrf-2
UR - http://www.scopus.com/inward/record.url?scp=85055077390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055077390&partnerID=8YFLogxK
U2 - 10.3390/nu10101521
DO - 10.3390/nu10101521
M3 - Article
C2 - 30336562
AN - SCOPUS:85055077390
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 10
ER -