Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension

Jiun Rong Chen, Jung Ko, Wan Ju Yeh, Wen Chih Huang, Hsin Yi Yang

研究成果: 雜誌貢獻 › 文章

2 引文 (Scopus)

摘要

Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day Nω-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction.
原文英語
期刊Nutrients
卷10
發行號10
DOIs
出版狀態已發佈 - 十月 17 2018

指紋

renoprotective effect
hypertension
arginine
esters
kidneys
Hypertension
rats
heme oxygenase (biliverdin-producing)
Renal Hypertension
endothelins
Blood Pressure
angiotensin II
diastolic blood pressure
Kidney
systolic blood pressure
renal function
blood vessels
NADP (coenzyme)
creatinine
malondialdehyde

Keywords

  • antroquinonol
  • hypertension
  • inflammation
  • nitric oxide
  • Nrf-2

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

引用此文

Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension. / Chen, Jiun Rong; Ko, Jung; Yeh, Wan Ju; Huang, Wen Chih; Yang, Hsin Yi.

於: Nutrients, 卷 10, 編號 10, 17.10.2018.

研究成果: 雜誌貢獻 › 文章

Chen, JR, Ko, J, Yeh, WJ, Huang, WC & Yang, HY 2018, 'Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension', Nutrients, 卷 10, 編號 10. https://doi.org/10.3390/nu10101521
Chen JR, Ko J, Yeh WJ, Huang WC, Yang HY. Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension. Nutrients. 2018 10月 17;10(10). https://doi.org/10.3390/nu10101521
Chen, Jiun Rong ; Ko, Jung ; Yeh, Wan Ju ; Huang, Wen Chih ; Yang, Hsin Yi. / Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension. 於: Nutrients. 2018 ; 卷 10, 編號 10.
@article{86276a13565b44e0bf8342715d7cff57,
title = "Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension",
abstract = "Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day Nω-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction.",
keywords = "antroquinonol, hypertension, inflammation, nitric oxide, Nrf-2, antroquinonol, hypertension, inflammation, nitric oxide, Nrf-2",
author = "Chen, {Jiun Rong} and Jung Ko and Yeh, {Wan Ju} and Huang, {Wen Chih} and Yang, {Hsin Yi}",
year = "2018",
month = "10",
day = "17",
doi = "10.3390/nu10101521",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",

}

TY - JOUR

T1 - Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension

AU - Chen, Jiun Rong

AU - Ko, Jung

AU - Yeh, Wan Ju

AU - Huang, Wen Chih

AU - Yang, Hsin Yi

PY - 2018/10/17

Y1 - 2018/10/17

N2 - Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day Nω-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction.

AB - Endothelial dysfunction leads to elevation of blood pressure and vascular remodeling, which may result in tissue injuries. The aim of this study was to investigate the mechanisms and effects of antroquinonol on hypertension and related renal injuries. Rats were fed water containing 25 mg/kg/day Nω-nitro-l-arginine methyl ester (L-NAME) to induce hypertension, and a diet with or without antroquinonol (20 or 40 mg/kg/day) for a 9-week experiment. During the experimental period, antroquinonol reduced the elevation of systolic and diastolic blood pressure. At the end of the study, we found that the antroquinonol groups had lower serum creatinine, renal endothelin-1, angiotensin II, and malondialdehyde levels and arteriole thickening. We found that the 40 mg/kg/day antroquinonol group had lower renal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activities, greater nuclear factor erythroid-2, and heme oxygenase-1 expressions. Moreover, we also found that antroquinonol decreased proinflammatory cytokine concentrations in the kidney by modulating the nuclear factor-κB pathway. These results suggest that antroquinonol may ameliorate hypertension and improve renal function by reducing oxidative stress and inflammation in rats with endothelial dysfunction.

KW - antroquinonol

KW - hypertension

KW - inflammation

KW - nitric oxide

KW - Nrf-2

KW - antroquinonol

KW - hypertension

KW - inflammation

KW - nitric oxide

KW - Nrf-2

UR - http://www.scopus.com/inward/record.url?scp=85055077390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055077390&partnerID=8YFLogxK

U2 - 10.3390/nu10101521

DO - 10.3390/nu10101521

M3 - Article

VL - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 10

ER -

存取文件