Renal insufficiency plays a crucial association factor in severe knee osteoarthritis-induced pain in patients with total knee replacement: A retrospective study

Chung Ching Chio, Man Kit Siu, Yu Ting Tai, Tyng Guey Chen, Wei Pin Ho, Jui Tai Chen, Hsiao Chien Tsai, Ruei Ming Chen

研究成果: 雜誌貢獻文章同行評審

摘要

Pain, the main symptom of osteoarthritis (OA), can lead to functional disability in patients with knee OA. Understanding the association factors related to knee pain is important since preventing OA-induced disabilities can be achieved by modifying these pain-associated issues. Therefore, this study was aimed to investigate the association factors for OA-induced knee pain in Taiwanese patients who received total knee replacements (TKR).In this retrospective study, 357 subjects who had undergone TKR at the Taipei Municipal Wan-Fang Hospital were recruited. The distribution of pain severity among patients with knee OA was evaluated. Demographic data and clinical parameters were analyzed to determine relationships between these variables and the severity of knee OA pain.Of the 357 patients studied, 54% and 33% had moderate and severe knee pain, respectively. Furthermore, a multivariate logistic regression analysis revealed that serum creatinine (>1.5mg/dL) and an estimated glomerular filtration rate (EGFR) (<60mL/min/1.73 m2) were significantly associated with severe knee pain in OA patients. A significant correlation between severe knee pain and serum creatinine or EGFR was demonstrated by Pearson correlations.Taken together, the renal insufficiency defined by an elevated serum creatinine or a low EGFR in OA patients who required TKR was associated with severe knee pain. These variables must be considered while treating knee OA pain, especially in those patients with severe pain.

原文英語
文章編號e19125
期刊Medicine (United States)
99
發行號6
DOIs
出版狀態已發佈 - 一月 1 2020

ASJC Scopus subject areas

  • Medicine(all)

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