Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease: A clinicopathologic study from nephrectomized kidneys

Tung Wei Hunga, Jia Hung Lioua, Kun Tu Yeh, Jen Pi Tsai, Sheng Wen Wu, Hui Chun Tai, Wei Tse Kao, Shu Hui Lin, Ya Wen Cheng, Horng Rong Chang

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

Background & objectives: Hypoxia inducible factor-1α (HIF-1α) has been shown to play a role in the pathogenesis of renal interstitial fibrosis. However, the relationship of HIF-1α expression intensity in human renal tissue with the degree of renal function or renal fibrosis has not been investigated. We therefore, undertook this study to assess the relationship between HIF-1α expression and degree of renal impairment and renal fibrosis using renal tissue from nephrectomized kidneys from patients with chronic kidney disease. Methods: This retrospective study was performed with 70 patients undergoing unilateral or bilateral nephrectomy because of renal cell carcinoma, urothelial cell carcinoma, or renal abscess. Immunohistochemical analysis of HIF-1α expression in non-tumourous or non-abscess renal parenchyma was performed. The patients were divided into two groups: group 1 (n=37) with low intensity HIF-1α expression and group 2 (n=33) with high intensity HIF-1α expression. Results: The intensity of renal HIF-1α expression was significantly associated with serum creatinine level (P=0.005), estimated glomerular filtration rate (P=0.02), fibrosis score of the interstitium (P=0.004) and glomerular sclerosis (P=0.013). A high intensity of HIF-1α expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis. In addition, multivariate analysis by step-wise logistic regression demonstrated that interstitial fibrosis was the only independent factor associated with the intensity of renal HIF-1α expression (OR 4.107, CI 1.535-11.313, P=0.005). Interpretation & conclusions: This study demonstrated a correlation between intensity of HIF-1α expression and degree of renal interstitial fibrosis. The association demonstrated an elevated HIF-1α expression in less severe kidney disease. The intensity of HIF-1α renal expression plays a role in the pathogenesis of chronic kidney disease.
原文英語
頁(從 - 到)102-110
頁數9
期刊Indian Journal of Medical Research
137
發行號1
出版狀態已發佈 - 一月 2013
對外發佈Yes

指紋

Hypoxia-Inducible Factor 1
Chronic Renal Insufficiency
Kidney
Fibrosis
Sclerosis
Glomerular Filtration Rate
Renal Cell Carcinoma
Creatinine
Cells
Tissue
Kidney Diseases
Nephrectomy
Serum
Logistics
Abscess

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

Hunga, T. W., Lioua, J. H., Yeh, K. T., Tsai, J. P., Wu, S. W., Tai, H. C., ... Chang, H. R. (2013). Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease: A clinicopathologic study from nephrectomized kidneys. Indian Journal of Medical Research, 137(1), 102-110.

Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease : A clinicopathologic study from nephrectomized kidneys. / Hunga, Tung Wei; Lioua, Jia Hung; Yeh, Kun Tu; Tsai, Jen Pi; Wu, Sheng Wen; Tai, Hui Chun; Kao, Wei Tse; Lin, Shu Hui; Cheng, Ya Wen; Chang, Horng Rong.

於: Indian Journal of Medical Research, 卷 137, 編號 1, 01.2013, p. 102-110.

研究成果: 雜誌貢獻文章

Hunga, TW, Lioua, JH, Yeh, KT, Tsai, JP, Wu, SW, Tai, HC, Kao, WT, Lin, SH, Cheng, YW & Chang, HR 2013, 'Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease: A clinicopathologic study from nephrectomized kidneys', Indian Journal of Medical Research, 卷 137, 編號 1, 頁 102-110.
Hunga, Tung Wei ; Lioua, Jia Hung ; Yeh, Kun Tu ; Tsai, Jen Pi ; Wu, Sheng Wen ; Tai, Hui Chun ; Kao, Wei Tse ; Lin, Shu Hui ; Cheng, Ya Wen ; Chang, Horng Rong. / Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease : A clinicopathologic study from nephrectomized kidneys. 於: Indian Journal of Medical Research. 2013 ; 卷 137, 編號 1. 頁 102-110.
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abstract = "Background & objectives: Hypoxia inducible factor-1α (HIF-1α) has been shown to play a role in the pathogenesis of renal interstitial fibrosis. However, the relationship of HIF-1α expression intensity in human renal tissue with the degree of renal function or renal fibrosis has not been investigated. We therefore, undertook this study to assess the relationship between HIF-1α expression and degree of renal impairment and renal fibrosis using renal tissue from nephrectomized kidneys from patients with chronic kidney disease. Methods: This retrospective study was performed with 70 patients undergoing unilateral or bilateral nephrectomy because of renal cell carcinoma, urothelial cell carcinoma, or renal abscess. Immunohistochemical analysis of HIF-1α expression in non-tumourous or non-abscess renal parenchyma was performed. The patients were divided into two groups: group 1 (n=37) with low intensity HIF-1α expression and group 2 (n=33) with high intensity HIF-1α expression. Results: The intensity of renal HIF-1α expression was significantly associated with serum creatinine level (P=0.005), estimated glomerular filtration rate (P=0.02), fibrosis score of the interstitium (P=0.004) and glomerular sclerosis (P=0.013). A high intensity of HIF-1α expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis. In addition, multivariate analysis by step-wise logistic regression demonstrated that interstitial fibrosis was the only independent factor associated with the intensity of renal HIF-1α expression (OR 4.107, CI 1.535-11.313, P=0.005). Interpretation & conclusions: This study demonstrated a correlation between intensity of HIF-1α expression and degree of renal interstitial fibrosis. The association demonstrated an elevated HIF-1α expression in less severe kidney disease. The intensity of HIF-1α renal expression plays a role in the pathogenesis of chronic kidney disease.",
keywords = "Chronic kidney disease, GFR, Hypoxia inducible factor-1α, Nephrectomy, Renal fibrosis, Renal function",
author = "Hunga, {Tung Wei} and Lioua, {Jia Hung} and Yeh, {Kun Tu} and Tsai, {Jen Pi} and Wu, {Sheng Wen} and Tai, {Hui Chun} and Kao, {Wei Tse} and Lin, {Shu Hui} and Cheng, {Ya Wen} and Chang, {Horng Rong}",
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AU - Hunga, Tung Wei

AU - Lioua, Jia Hung

AU - Yeh, Kun Tu

AU - Tsai, Jen Pi

AU - Wu, Sheng Wen

AU - Tai, Hui Chun

AU - Kao, Wei Tse

AU - Lin, Shu Hui

AU - Cheng, Ya Wen

AU - Chang, Horng Rong

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N2 - Background & objectives: Hypoxia inducible factor-1α (HIF-1α) has been shown to play a role in the pathogenesis of renal interstitial fibrosis. However, the relationship of HIF-1α expression intensity in human renal tissue with the degree of renal function or renal fibrosis has not been investigated. We therefore, undertook this study to assess the relationship between HIF-1α expression and degree of renal impairment and renal fibrosis using renal tissue from nephrectomized kidneys from patients with chronic kidney disease. Methods: This retrospective study was performed with 70 patients undergoing unilateral or bilateral nephrectomy because of renal cell carcinoma, urothelial cell carcinoma, or renal abscess. Immunohistochemical analysis of HIF-1α expression in non-tumourous or non-abscess renal parenchyma was performed. The patients were divided into two groups: group 1 (n=37) with low intensity HIF-1α expression and group 2 (n=33) with high intensity HIF-1α expression. Results: The intensity of renal HIF-1α expression was significantly associated with serum creatinine level (P=0.005), estimated glomerular filtration rate (P=0.02), fibrosis score of the interstitium (P=0.004) and glomerular sclerosis (P=0.013). A high intensity of HIF-1α expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis. In addition, multivariate analysis by step-wise logistic regression demonstrated that interstitial fibrosis was the only independent factor associated with the intensity of renal HIF-1α expression (OR 4.107, CI 1.535-11.313, P=0.005). Interpretation & conclusions: This study demonstrated a correlation between intensity of HIF-1α expression and degree of renal interstitial fibrosis. The association demonstrated an elevated HIF-1α expression in less severe kidney disease. The intensity of HIF-1α renal expression plays a role in the pathogenesis of chronic kidney disease.

AB - Background & objectives: Hypoxia inducible factor-1α (HIF-1α) has been shown to play a role in the pathogenesis of renal interstitial fibrosis. However, the relationship of HIF-1α expression intensity in human renal tissue with the degree of renal function or renal fibrosis has not been investigated. We therefore, undertook this study to assess the relationship between HIF-1α expression and degree of renal impairment and renal fibrosis using renal tissue from nephrectomized kidneys from patients with chronic kidney disease. Methods: This retrospective study was performed with 70 patients undergoing unilateral or bilateral nephrectomy because of renal cell carcinoma, urothelial cell carcinoma, or renal abscess. Immunohistochemical analysis of HIF-1α expression in non-tumourous or non-abscess renal parenchyma was performed. The patients were divided into two groups: group 1 (n=37) with low intensity HIF-1α expression and group 2 (n=33) with high intensity HIF-1α expression. Results: The intensity of renal HIF-1α expression was significantly associated with serum creatinine level (P=0.005), estimated glomerular filtration rate (P=0.02), fibrosis score of the interstitium (P=0.004) and glomerular sclerosis (P=0.013). A high intensity of HIF-1α expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis. In addition, multivariate analysis by step-wise logistic regression demonstrated that interstitial fibrosis was the only independent factor associated with the intensity of renal HIF-1α expression (OR 4.107, CI 1.535-11.313, P=0.005). Interpretation & conclusions: This study demonstrated a correlation between intensity of HIF-1α expression and degree of renal interstitial fibrosis. The association demonstrated an elevated HIF-1α expression in less severe kidney disease. The intensity of HIF-1α renal expression plays a role in the pathogenesis of chronic kidney disease.

KW - Chronic kidney disease

KW - GFR

KW - Hypoxia inducible factor-1α

KW - Nephrectomy

KW - Renal fibrosis

KW - Renal function

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