Renal effects and urinary excretion of prostaglandin following indomethacin therapy in premature infants with patent ductus arteriosus.

Y. J. Lin, Y. J. Tsai, J. S. Chen, J. S. Lin, J. M. Wu, C. H. Lin, T. F. Yeh

研究成果: 雜誌貢獻文章

12 引文 (Scopus)

摘要

Renal side effects and urinary prostaglandin were evaluated in 10 premature infants (Mean +/- SD: BW 1245 +/- 290 gm, GA 32 +/- 2.2 wks, Postnatal age 7.7 +/- 3.8 days) with significant PDA who were given one dose of indomethacin (0.3 mg/kg intravenously). There was a significant decrease in urinary output, osmolal and free water clearance after therapy. The fractional excretion of sodium, chloride, potassium, glomerular filtration rate and urinary prostaglandin E2 also decreased but were not statistically different from the baseline values. In infants who responded to indomethacin with ductus closure, their renal functions appeared to be preserved even though they had higher plasma indomethacin levels than the non-responders in whom significant changes in renal function were observed following indomethacin therapy. This observation suggested that the improved renal hemodynamics following the closure of the ductus may minimize or attenuate the renal side effects of indomethacin.

原文英語
頁(從 - 到)104-107
頁數4
期刊Acta Paediatrica Sinica
36
發行號2
出版狀態已發佈 - 三月 1 1995
對外發佈Yes

指紋

Patent Ductus Arteriosus
Premature Infants
Indomethacin
Prostaglandins
Kidney
Therapeutics
Glomerular Filtration Rate
Dinoprostone
Sodium Chloride
Potassium
Hemodynamics
Water

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

引用此文

Renal effects and urinary excretion of prostaglandin following indomethacin therapy in premature infants with patent ductus arteriosus. / Lin, Y. J.; Tsai, Y. J.; Chen, J. S.; Lin, J. S.; Wu, J. M.; Lin, C. H.; Yeh, T. F.

於: Acta Paediatrica Sinica, 卷 36, 編號 2, 01.03.1995, p. 104-107.

研究成果: 雜誌貢獻文章

Lin, Y. J. ; Tsai, Y. J. ; Chen, J. S. ; Lin, J. S. ; Wu, J. M. ; Lin, C. H. ; Yeh, T. F. / Renal effects and urinary excretion of prostaglandin following indomethacin therapy in premature infants with patent ductus arteriosus. 於: Acta Paediatrica Sinica. 1995 ; 卷 36, 編號 2. 頁 104-107.
@article{b602f35605e04fb2941800caef66394e,
title = "Renal effects and urinary excretion of prostaglandin following indomethacin therapy in premature infants with patent ductus arteriosus.",
abstract = "Renal side effects and urinary prostaglandin were evaluated in 10 premature infants (Mean +/- SD: BW 1245 +/- 290 gm, GA 32 +/- 2.2 wks, Postnatal age 7.7 +/- 3.8 days) with significant PDA who were given one dose of indomethacin (0.3 mg/kg intravenously). There was a significant decrease in urinary output, osmolal and free water clearance after therapy. The fractional excretion of sodium, chloride, potassium, glomerular filtration rate and urinary prostaglandin E2 also decreased but were not statistically different from the baseline values. In infants who responded to indomethacin with ductus closure, their renal functions appeared to be preserved even though they had higher plasma indomethacin levels than the non-responders in whom significant changes in renal function were observed following indomethacin therapy. This observation suggested that the improved renal hemodynamics following the closure of the ductus may minimize or attenuate the renal side effects of indomethacin.",
author = "Lin, {Y. J.} and Tsai, {Y. J.} and Chen, {J. S.} and Lin, {J. S.} and Wu, {J. M.} and Lin, {C. H.} and Yeh, {T. F.}",
year = "1995",
month = "3",
day = "1",
language = "English",
volume = "36",
pages = "104--107",
journal = "Pediatrics and Neonatology",
issn = "1875-9572",
publisher = "臺灣兒科醫學會",
number = "2",

}

TY - JOUR

T1 - Renal effects and urinary excretion of prostaglandin following indomethacin therapy in premature infants with patent ductus arteriosus.

AU - Lin, Y. J.

AU - Tsai, Y. J.

AU - Chen, J. S.

AU - Lin, J. S.

AU - Wu, J. M.

AU - Lin, C. H.

AU - Yeh, T. F.

PY - 1995/3/1

Y1 - 1995/3/1

N2 - Renal side effects and urinary prostaglandin were evaluated in 10 premature infants (Mean +/- SD: BW 1245 +/- 290 gm, GA 32 +/- 2.2 wks, Postnatal age 7.7 +/- 3.8 days) with significant PDA who were given one dose of indomethacin (0.3 mg/kg intravenously). There was a significant decrease in urinary output, osmolal and free water clearance after therapy. The fractional excretion of sodium, chloride, potassium, glomerular filtration rate and urinary prostaglandin E2 also decreased but were not statistically different from the baseline values. In infants who responded to indomethacin with ductus closure, their renal functions appeared to be preserved even though they had higher plasma indomethacin levels than the non-responders in whom significant changes in renal function were observed following indomethacin therapy. This observation suggested that the improved renal hemodynamics following the closure of the ductus may minimize or attenuate the renal side effects of indomethacin.

AB - Renal side effects and urinary prostaglandin were evaluated in 10 premature infants (Mean +/- SD: BW 1245 +/- 290 gm, GA 32 +/- 2.2 wks, Postnatal age 7.7 +/- 3.8 days) with significant PDA who were given one dose of indomethacin (0.3 mg/kg intravenously). There was a significant decrease in urinary output, osmolal and free water clearance after therapy. The fractional excretion of sodium, chloride, potassium, glomerular filtration rate and urinary prostaglandin E2 also decreased but were not statistically different from the baseline values. In infants who responded to indomethacin with ductus closure, their renal functions appeared to be preserved even though they had higher plasma indomethacin levels than the non-responders in whom significant changes in renal function were observed following indomethacin therapy. This observation suggested that the improved renal hemodynamics following the closure of the ductus may minimize or attenuate the renal side effects of indomethacin.

UR - http://www.scopus.com/inward/record.url?scp=0029268798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029268798&partnerID=8YFLogxK

M3 - Article

C2 - 7793274

AN - SCOPUS:0029268798

VL - 36

SP - 104

EP - 107

JO - Pediatrics and Neonatology

JF - Pediatrics and Neonatology

SN - 1875-9572

IS - 2

ER -