Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats

Wann Chu Huang, Te Chao Fang, Juei Tang Cheng

研究成果: 雜誌貢獻文章

50 引文 斯高帕斯(Scopus)

摘要

Experiments were performed to evaluate the role of the renal nerves in hyperinsulinemia-induced hypertension. Male Sprague-Dawley rats were made hyperinsulinemic by insulin infusion via osmotic minipumps implanted subcutaneously (3.0 mU/kg per minute for 6 weeks). Rats with vehicle infusion served as controls. Bilateral renal denervation was performed either at the beginning of or 4 weeks after insulin infusion. The systolic blood pressure was measured by the tail-cuff method twice a week. Food and water intake and urine flow were measured daily. The results showed that sustained insulin infusion significantly increased plasma insulin concentrations from 277.7±25.8 pmol/L to 609.9±22.2 and 696.7±23.0 pmol/L by the end of weeks 4 and 6, respectively (P

原文英語
頁(從 - 到)249-254
頁數6
期刊Hypertension
32
發行號2
出版狀態已發佈 - 八月 1998
對外發佈Yes

ASJC Scopus subject areas

  • Internal Medicine

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