Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats

Wann Chu Huang, Te Chao Fang, Juei Tang Cheng

研究成果: 雜誌貢獻文章

50 引文 (Scopus)

摘要

Experiments were performed to evaluate the role of the renal nerves in hyperinsulinemia-induced hypertension. Male Sprague-Dawley rats were made hyperinsulinemic by insulin infusion via osmotic minipumps implanted subcutaneously (3.0 mU/kg per minute for 6 weeks). Rats with vehicle infusion served as controls. Bilateral renal denervation was performed either at the beginning of or 4 weeks after insulin infusion. The systolic blood pressure was measured by the tail-cuff method twice a week. Food and water intake and urine flow were measured daily. The results showed that sustained insulin infusion significantly increased plasma insulin concentrations from 277.7±25.8 pmol/L to 609.9±22.2 and 696.7±23.0 pmol/L by the end of weeks 4 and 6, respectively (P

原文英語
頁(從 - 到)249-254
頁數6
期刊Hypertension
32
發行號2
出版狀態已發佈 - 八月 1998
對外發佈Yes

指紋

Hyperinsulinism
Denervation
Insulin
Hypertension
Kidney
Blood Pressure
Drinking
Sprague Dawley Rats
Tail
Eating
Urine

ASJC Scopus subject areas

  • Internal Medicine

引用此文

Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats. / Huang, Wann Chu; Fang, Te Chao; Cheng, Juei Tang.

於: Hypertension, 卷 32, 編號 2, 08.1998, p. 249-254.

研究成果: 雜誌貢獻文章

Huang, Wann Chu ; Fang, Te Chao ; Cheng, Juei Tang. / Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats. 於: Hypertension. 1998 ; 卷 32, 編號 2. 頁 249-254.
@article{a239090031fd4e42bd3161eb35e1a4ec,
title = "Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats",
abstract = "Experiments were performed to evaluate the role of the renal nerves in hyperinsulinemia-induced hypertension. Male Sprague-Dawley rats were made hyperinsulinemic by insulin infusion via osmotic minipumps implanted subcutaneously (3.0 mU/kg per minute for 6 weeks). Rats with vehicle infusion served as controls. Bilateral renal denervation was performed either at the beginning of or 4 weeks after insulin infusion. The systolic blood pressure was measured by the tail-cuff method twice a week. Food and water intake and urine flow were measured daily. The results showed that sustained insulin infusion significantly increased plasma insulin concentrations from 277.7±25.8 pmol/L to 609.9±22.2 and 696.7±23.0 pmol/L by the end of weeks 4 and 6, respectively (P",
keywords = "Denervated natriuresis, Hyperinsulinemia, Insulin resistance, Renal denervation, Renal nerve",
author = "Huang, {Wann Chu} and Fang, {Te Chao} and Cheng, {Juei Tang}",
year = "1998",
month = "8",
language = "English",
volume = "32",
pages = "249--254",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats

AU - Huang, Wann Chu

AU - Fang, Te Chao

AU - Cheng, Juei Tang

PY - 1998/8

Y1 - 1998/8

N2 - Experiments were performed to evaluate the role of the renal nerves in hyperinsulinemia-induced hypertension. Male Sprague-Dawley rats were made hyperinsulinemic by insulin infusion via osmotic minipumps implanted subcutaneously (3.0 mU/kg per minute for 6 weeks). Rats with vehicle infusion served as controls. Bilateral renal denervation was performed either at the beginning of or 4 weeks after insulin infusion. The systolic blood pressure was measured by the tail-cuff method twice a week. Food and water intake and urine flow were measured daily. The results showed that sustained insulin infusion significantly increased plasma insulin concentrations from 277.7±25.8 pmol/L to 609.9±22.2 and 696.7±23.0 pmol/L by the end of weeks 4 and 6, respectively (P

AB - Experiments were performed to evaluate the role of the renal nerves in hyperinsulinemia-induced hypertension. Male Sprague-Dawley rats were made hyperinsulinemic by insulin infusion via osmotic minipumps implanted subcutaneously (3.0 mU/kg per minute for 6 weeks). Rats with vehicle infusion served as controls. Bilateral renal denervation was performed either at the beginning of or 4 weeks after insulin infusion. The systolic blood pressure was measured by the tail-cuff method twice a week. Food and water intake and urine flow were measured daily. The results showed that sustained insulin infusion significantly increased plasma insulin concentrations from 277.7±25.8 pmol/L to 609.9±22.2 and 696.7±23.0 pmol/L by the end of weeks 4 and 6, respectively (P

KW - Denervated natriuresis

KW - Hyperinsulinemia

KW - Insulin resistance

KW - Renal denervation

KW - Renal nerve

UR - http://www.scopus.com/inward/record.url?scp=0031817065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031817065&partnerID=8YFLogxK

M3 - Article

C2 - 9719050

AN - SCOPUS:0031817065

VL - 32

SP - 249

EP - 254

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 2

ER -