Renal cell carcinoma. Cytogenetic analysis of tumors and cell lines

W. P. Zhao, J. R. Gnarra, S. Liu, T. Knutsen, W. M. Linehan, J. Whang-Peng

研究成果: 雜誌貢獻文章

34 引文 (Scopus)

摘要

Successful cytogenetic analysis was performed on 27 samples from 25 patients with RCC, including 7 of 11 tumors studied and 20 cell lines. Clonal chromosomal abnormalities were detected in all 27 samples. The most frequently involved chromosomes were 7, 1, 3, 9, and the Y (20, 17, 17, 14, and 10 cases, respectively). Polysomy 7 or rearrangement of 7q was seen in 80% ( 20 25) of the patients, and loss or rearrangement of 3p was seen in 48% ( 12 25); of the latter, four patients had loss of the whole chromosome and 10 patients had deletions or translocations involving 3p, with breakpoints at either 3p11-14 or 3p21-23 ( 5 7 translocation breakpoints were at 3p21-23). Loss of the sex chromosomes was seen in 15 patients, including -Y in 10 22 males. Other clonal changes included structural abnormalities of chromosome 1 centromere and the long arm, breakpoints at or near the centromere of chromosome 9 (10 patients), polysomy 16, monosomy 17, polysomy 20, and monosomy 22. With the exception of chromosome 3p loss, which was primarily confined to the nonpapillary cases, no specific clonal abnormality was noted for any particular subtype of RCC. Trisomy or tetrasomy 7 and -Y were seen in all subtypes of renal cell carcinoma.
原文英語
頁(從 - 到)128-139
頁數12
期刊Cancer Genetics and Cytogenetics
82
發行號2
DOIs
出版狀態已發佈 - 七月 15 1995
對外發佈Yes

指紋

Cytogenetic Analysis
Tumor Cell Line
Renal Cell Carcinoma
Monosomy
Chromosomes, Human, Pair 10
Centromere
Tetrasomy
Chromosomes, Human, Pair 9
Sex Chromosomes
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 1
Trisomy
Chromosome Aberrations
Chromosomes
Cell Line
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

引用此文

Renal cell carcinoma. Cytogenetic analysis of tumors and cell lines. / Zhao, W. P.; Gnarra, J. R.; Liu, S.; Knutsen, T.; Linehan, W. M.; Whang-Peng, J.

於: Cancer Genetics and Cytogenetics, 卷 82, 編號 2, 15.07.1995, p. 128-139.

研究成果: 雜誌貢獻文章

Zhao, W. P. ; Gnarra, J. R. ; Liu, S. ; Knutsen, T. ; Linehan, W. M. ; Whang-Peng, J. / Renal cell carcinoma. Cytogenetic analysis of tumors and cell lines. 於: Cancer Genetics and Cytogenetics. 1995 ; 卷 82, 編號 2. 頁 128-139.
@article{c46d6335bf784e9183a55954e5bac775,
title = "Renal cell carcinoma. Cytogenetic analysis of tumors and cell lines",
abstract = "Successful cytogenetic analysis was performed on 27 samples from 25 patients with RCC, including 7 of 11 tumors studied and 20 cell lines. Clonal chromosomal abnormalities were detected in all 27 samples. The most frequently involved chromosomes were 7, 1, 3, 9, and the Y (20, 17, 17, 14, and 10 cases, respectively). Polysomy 7 or rearrangement of 7q was seen in 80{\%} ( 20 25) of the patients, and loss or rearrangement of 3p was seen in 48{\%} ( 12 25); of the latter, four patients had loss of the whole chromosome and 10 patients had deletions or translocations involving 3p, with breakpoints at either 3p11-14 or 3p21-23 ( 5 7 translocation breakpoints were at 3p21-23). Loss of the sex chromosomes was seen in 15 patients, including -Y in 10 22 males. Other clonal changes included structural abnormalities of chromosome 1 centromere and the long arm, breakpoints at or near the centromere of chromosome 9 (10 patients), polysomy 16, monosomy 17, polysomy 20, and monosomy 22. With the exception of chromosome 3p loss, which was primarily confined to the nonpapillary cases, no specific clonal abnormality was noted for any particular subtype of RCC. Trisomy or tetrasomy 7 and -Y were seen in all subtypes of renal cell carcinoma.",
author = "Zhao, {W. P.} and Gnarra, {J. R.} and S. Liu and T. Knutsen and Linehan, {W. M.} and J. Whang-Peng",
year = "1995",
month = "7",
day = "15",
doi = "10.1016/0165-4608(95)00024-J",
language = "English",
volume = "82",
pages = "128--139",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Renal cell carcinoma. Cytogenetic analysis of tumors and cell lines

AU - Zhao, W. P.

AU - Gnarra, J. R.

AU - Liu, S.

AU - Knutsen, T.

AU - Linehan, W. M.

AU - Whang-Peng, J.

PY - 1995/7/15

Y1 - 1995/7/15

N2 - Successful cytogenetic analysis was performed on 27 samples from 25 patients with RCC, including 7 of 11 tumors studied and 20 cell lines. Clonal chromosomal abnormalities were detected in all 27 samples. The most frequently involved chromosomes were 7, 1, 3, 9, and the Y (20, 17, 17, 14, and 10 cases, respectively). Polysomy 7 or rearrangement of 7q was seen in 80% ( 20 25) of the patients, and loss or rearrangement of 3p was seen in 48% ( 12 25); of the latter, four patients had loss of the whole chromosome and 10 patients had deletions or translocations involving 3p, with breakpoints at either 3p11-14 or 3p21-23 ( 5 7 translocation breakpoints were at 3p21-23). Loss of the sex chromosomes was seen in 15 patients, including -Y in 10 22 males. Other clonal changes included structural abnormalities of chromosome 1 centromere and the long arm, breakpoints at or near the centromere of chromosome 9 (10 patients), polysomy 16, monosomy 17, polysomy 20, and monosomy 22. With the exception of chromosome 3p loss, which was primarily confined to the nonpapillary cases, no specific clonal abnormality was noted for any particular subtype of RCC. Trisomy or tetrasomy 7 and -Y were seen in all subtypes of renal cell carcinoma.

AB - Successful cytogenetic analysis was performed on 27 samples from 25 patients with RCC, including 7 of 11 tumors studied and 20 cell lines. Clonal chromosomal abnormalities were detected in all 27 samples. The most frequently involved chromosomes were 7, 1, 3, 9, and the Y (20, 17, 17, 14, and 10 cases, respectively). Polysomy 7 or rearrangement of 7q was seen in 80% ( 20 25) of the patients, and loss or rearrangement of 3p was seen in 48% ( 12 25); of the latter, four patients had loss of the whole chromosome and 10 patients had deletions or translocations involving 3p, with breakpoints at either 3p11-14 or 3p21-23 ( 5 7 translocation breakpoints were at 3p21-23). Loss of the sex chromosomes was seen in 15 patients, including -Y in 10 22 males. Other clonal changes included structural abnormalities of chromosome 1 centromere and the long arm, breakpoints at or near the centromere of chromosome 9 (10 patients), polysomy 16, monosomy 17, polysomy 20, and monosomy 22. With the exception of chromosome 3p loss, which was primarily confined to the nonpapillary cases, no specific clonal abnormality was noted for any particular subtype of RCC. Trisomy or tetrasomy 7 and -Y were seen in all subtypes of renal cell carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0029165763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029165763&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(95)00024-J

DO - 10.1016/0165-4608(95)00024-J

M3 - Article

C2 - 7664242

AN - SCOPUS:0029165763

VL - 82

SP - 128

EP - 139

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 2

ER -