Remote organ failure in acute kidney injury

Chih Chin Kao, Wei Shun Yang, Ji Tseng Fang, Kathleen D. Liu, Vin Cent Wu

研究成果: 雜誌貢獻回顧型文獻

3 引文 (Scopus)

摘要

Despite supportive care with renal replacement therapy, acute kidney injury (AKI) remains linked with increased short and long-term mortality, not just because of renal failure but also because of accompanying remote organ dysfunction. Increasing evidence from animal studies suggests that numerous factors contribute both to the development of AKI and the impairment of various vital organs, including pro-inflammatory cytokine expression, leukocyte infiltration, vascular permeability changes, ion channel derangement, oxidative stress, and cell apoptosis. Human studies have reported that AKI with concomitant multi-organ dysfunction is associated with a high death rate. We propose that persistent organ dysfunction after AKI can be considered in relation to three proposed mechanisms (1) classical uremic stress and its associated sequelae (2) systemic inflammation as a consequence of kidney injury (3) treatment-related effects. Using this framework, we discuss the known pathways through which AKI can affect the function of a number of remote organs. We review the short- and long-term clinical impact of AKI on other organ systems and potential mechanisms through which AKI may affect remote organ systems. Further elucidating the effects of AKI on remote organ function may lead to new therapeutic strategies to improve outcomes after AKI.
原文英語
頁(從 - 到)859-866
頁數8
期刊Journal of the Formosan Medical Association
118
發行號5
DOIs
出版狀態已發佈 - 五月 1 2019

指紋

Acute Kidney Injury
Renal Replacement Therapy
Mortality
Capillary Permeability
Ion Channels
Renal Insufficiency
Oxidative Stress
Leukocytes
Apoptosis
Cytokines
Inflammation
Kidney
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Remote organ failure in acute kidney injury. / Kao, Chih Chin; Yang, Wei Shun; Fang, Ji Tseng; Liu, Kathleen D.; Wu, Vin Cent.

於: Journal of the Formosan Medical Association, 卷 118, 編號 5, 01.05.2019, p. 859-866.

研究成果: 雜誌貢獻回顧型文獻

Kao, Chih Chin ; Yang, Wei Shun ; Fang, Ji Tseng ; Liu, Kathleen D. ; Wu, Vin Cent. / Remote organ failure in acute kidney injury. 於: Journal of the Formosan Medical Association. 2019 ; 卷 118, 編號 5. 頁 859-866.
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