Release of indomethacin from a novel chitosan microsphere prepared by a naturally occurring crosslinker: Examination of crosslinking and polycation-anionic drug interaction

Fwu Long Mi, Hsing Wen Sung, Shin Shing Shyu

研究成果: 雜誌貢獻文章同行評審

80 引文 斯高帕斯(Scopus)

摘要

Novel chitosan microspheres with lower cytotoxicity were fabricated in this study and their drug release characteristics were investigated. Genipin, a naturally occurring crosslinking reagent that has been used in herbal medicine and in the production of food dye, was used to prepare crosslinked chitosan microspheres by a water-in-oil dispersion method. The crosslinking mechanism examined by FTIR and 13C-NMR suggests that the crosslinking of chitosan by genipin leads to the formation of secondary amide and heterocyclic amino linkage. The polycation-anionic drug interaction between chitosan and indomethacin was pH dependent and could affect the dissolution property of indomethacin. By examination of the release profiles of the crosslinked chitosan microsphere, it was found that the release of indomethacin from the microsphere was sustainable and influenced by factors such as crosslinking of microsphere and chitosan-indomethacin interaction, thus establishing crosslinked chitosan microsphere as a very promising polymeric carrier for drug release.

原文英語
頁(從 - 到)1700-1711
頁數12
期刊Journal of Applied Polymer Science
81
發行號7
DOIs
出版狀態已發佈 - 八月 15 2001
對外發佈

ASJC Scopus subject areas

  • 聚合物和塑料

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