Relative cardiotoxicity and cytotoxicity of anthraquinonyl glucosaminosides

Jon W. Banning, Hanley N. Abramson, Henry C. Wormser, Jender Wu, Thomas H. Corbett

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

The cardiotoxicity and cytotoxicity for tumor cells of four new synthetic anthraquinonyl glucosaminosides were compared in vitro. The nonhydroxylated anthraquinone was not cardiotoxic, and its cytotoxic activity was the weakest of the compounds in the series. Increasing the number of hydroxyl groups on the anthraquinone moiety increased the inhibition of growth of L-1210 leukemia cells and pancreatic or colonic adenocarcinomas in a soft agar colony formation assay. However, cardiotoxicity was also increased in proportion to the number of hydroxyl groups present. The adenocarcinomas were slightly more sensitive than the leukemias to the inhibitory action of the dihydroxylated anthraquinonyl glucosaminosides on cell growth.
原文英語
頁(從 - 到)207-212
頁數6
期刊Cancer Chemotherapy and Pharmacology
19
發行號3
DOIs
出版狀態已發佈 - 五月 1987
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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